Protein Info for GFF6424 in Variovorax sp. SCN45

Annotation: Phosphoenolpyruvate carboxykinase [GTP] (EC 4.1.1.32)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 623 PF17297: PEPCK_N" amino acids 25 to 244 (220 residues), 353.6 bits, see alignment E=4.1e-110 PF00821: PEPCK_GTP" amino acids 248 to 620 (373 residues), 532.9 bits, see alignment E=3.1e-164

Best Hits

Swiss-Prot: 76% identical to PCKG_RALSO: Phosphoenolpyruvate carboxykinase [GTP] (pckG) from Ralstonia solanacearum (strain GMI1000)

KEGG orthology group: K01596, phosphoenolpyruvate carboxykinase (GTP) [EC: 4.1.1.32] (inferred from 94% identity to vpe:Varpa_0172)

Predicted SEED Role

"Phosphoenolpyruvate carboxykinase [GTP] (EC 4.1.1.32)" in subsystem Pyruvate metabolism I: anaplerotic reactions, PEP (EC 4.1.1.32)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 4.1.1.32

Use Curated BLAST to search for 4.1.1.32

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (623 amino acids)

>GFF6424 Phosphoenolpyruvate carboxykinase [GTP] (EC 4.1.1.32) (Variovorax sp. SCN45)
MNAPTMKGLTIQAPSYVKNAKLIAWVADMAALCKPEAIHWCDGSKEEYDRLCQQLVDAGT
FKKLNPVKRPNSFLAVSDPSDVARVEDRTYICSAQKENAGPTNNWMAPAEMRATLQPLFD
GCMKGRTMYVVPFSMGPLGSPIAHIGIELSDSPYVAVNMRIMTRMGKAVYDVLGTDGEFV
PCVHTVGAPLEAGQKDVSWPCNKTKYIVHYPETREIWSYGSGYGGNALLGKKCFALRIAS
NMGRDEGWLAEHMLILGVTNPEGKKYHVAAAFPSACGKTNFSMLVPPAGFEGWKVTTIGD
DIAWIKPQADGSLRAINPEAGYFGVAPGTNMLTNPNCMRSLDDGVIFTNVALTDDGDVWW
EGMEQDAPGKALPAHLIDWQGKDWTPQIAKETGAKAAHPNARFTVAATNNPALDEAWDDP
KGVTIDAFIFGGRRSTTVPLVTEARNWVEGVYMAATMGSETTAAAAGQQGVVRRDPFAML
PFMGYNMSDYFQHWLDLGKKLEASGAKLPKIYTTNWFRKGADGKFVWPGYGENMRVLKWM
IDRVEGNKTEGVEHITGVSPRYEDLNWTGLDFSAEQFATVTSIDKAAWEAELKLHAELFK
QLEHHLPKELPETKAAIEQRLAA