Protein Info for GFF637 in Variovorax sp. SCN45

Annotation: Two-component system sensor histidine kinase/response regulator hybrid

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1130 transmembrane" amino acids 45 to 69 (25 residues), see Phobius details amino acids 75 to 97 (23 residues), see Phobius details amino acids 118 to 143 (26 residues), see Phobius details amino acids 149 to 170 (22 residues), see Phobius details amino acids 178 to 197 (20 residues), see Phobius details amino acids 219 to 239 (21 residues), see Phobius details amino acids 259 to 287 (29 residues), see Phobius details amino acids 316 to 336 (21 residues), see Phobius details amino acids 361 to 383 (23 residues), see Phobius details amino acids 389 to 407 (19 residues), see Phobius details amino acids 428 to 449 (22 residues), see Phobius details amino acids 457 to 476 (20 residues), see Phobius details amino acids 569 to 590 (22 residues), see Phobius details amino acids 603 to 626 (24 residues), see Phobius details PF00512: HisKA" amino acids 672 to 737 (66 residues), 65 bits, see alignment 7.6e-22 PF02518: HATPase_c" amino acids 785 to 893 (109 residues), 86.6 bits, see alignment E=2.4e-28 PF00072: Response_reg" amino acids 923 to 1032 (110 residues), 71.4 bits, see alignment E=1.1e-23

Best Hits

KEGG orthology group: None (inferred from 95% identity to vpe:Varpa_3567)

Predicted SEED Role

"Two-component hybrid sensor and regulator"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1130 amino acids)

>GFF637 Two-component system sensor histidine kinase/response regulator hybrid (Variovorax sp. SCN45)
MQSVSGQKIFRIRRDYNAWVANETLEDYALRYTPRSFRKWSEFRVANAAFGATSFLALEA
IGGAIALSYGFSNALWAILVVGLITFLTGLPISYYAARHGVDMDLLTRGAGFGYLGSTLT
SLIYASFTFIFFALEAAILALALQMYLDWPLWLLYLVSSIVIIPLVARGITLISGLQLWT
QPIWIVLFVCPFIAVLVKKPELYADFTGLVGRTSDSSGFDPLMFGAAATVAFSLVVQIGE
QVDYLRFLPEKTAANRVRWWTAVLVAGPGWIVPGMLKMMGGAFLAFLALQHEIPAVHAIE
PTQMYLTGFSYVLRDPAWVLGVTVLFVVVSQMKINLTNAYAGSLAWSNFFARLTHSHPGR
VVWLVFNVVIAILLMALGVFAALEHVLGFYSNIAIAWVGALVADLVINKPLGWSPKTIEF
KRAHLYDINPVGLMAMLVAAALAMLAYSGALGHWAKAFSPFIALVTAMAVSPLLAWRTRG
RYYLARNDIERWAPGQSVKCSVCDNSFESEDMAHCPAYSAPICSLCCTLESRCHDRCKTD
SRAAEQMSGWLQALLPPALSARLNFRVAHYLMVAASLIALLATVVGVVYAQEAIAGTSDS
TMATAFLKVFALLSVVAAVAAWWVVLGSESRQMAQEESNRHNNLLALEIEAHRRTDAALQ
TAKEAAEAANQAKTRYVAGMTHELRTPLNSILGYSQILLKGDAVTPPREAVQTIHRSGEH
MLGLIDGLLDLARIEAGRLQLEPAPLALPAFLDQLVHMVRPQAENKGLAFVYTHAGRLPP
WVHADAKWLRQILINLLTNAVRFTDSGTVTLHVDARREVLRFDVVDTGIGVAPQDHQRIF
LPFERGAAGRRRGEPGTGLGLTITGLLTSLMGGELKLASTSSQGSTFSVRVYLREVADPG
PQARAGAPRQPVSGYLGARRTLLVVDDQPVQRQMLAGMLAPLGFEVREAASGTECLDSLR
EELPSAILLDLTMDDMDGWQTATSVRASGFGDIPIIIVSANMFENQAERLRAAGCQAFVG
KPVIESELIATLERHLGLEWLSPGDTPPRGDDEAAPLRPRRLELSEDDRAELMRLVQMGH
VRGLHTALDRLAAASPSAAATCTWLRGMVARFELDNLRNALAEDADTLAP