Protein Info for GFF6304 in Variovorax sp. SCN45
Annotation: Biosynthetic Aromatic amino acid aminotransferase beta (EC 2.6.1.57)
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 62% identical to HIS81_CUPNJ: Histidinol-phosphate aminotransferase 1 (hisC1) from Cupriavidus necator (strain JMP 134 / LMG 1197)
KEGG orthology group: K00817, histidinol-phosphate aminotransferase [EC: 2.6.1.9] (inferred from 90% identity to vpe:Varpa_0472)Predicted SEED Role
"Biosynthetic Aromatic amino acid aminotransferase beta (EC 2.6.1.57)" in subsystem Phenylalanine and Tyrosine Branches from Chorismate (EC 2.6.1.57)
MetaCyc Pathways
- superpathway of histidine, purine, and pyrimidine biosynthesis (43/46 steps found)
- superpathway of aromatic amino acid biosynthesis (18/18 steps found)
- L-histidine biosynthesis (10/10 steps found)
- superpathway of L-phenylalanine biosynthesis (10/10 steps found)
- superpathway of L-tyrosine biosynthesis (10/10 steps found)
- L-tyrosine degradation I (5/5 steps found)
- L-phenylalanine biosynthesis I (3/3 steps found)
- L-tyrosine biosynthesis I (3/3 steps found)
- L-phenylalanine biosynthesis III (cytosolic, plants) (2/2 steps found)
- 3-(4-hydroxyphenyl)pyruvate biosynthesis (1/1 steps found)
- L-phenylalanine biosynthesis II (3/4 steps found)
- L-tyrosine biosynthesis III (3/4 steps found)
- L-phenylalanine degradation II (anaerobic) (2/3 steps found)
- superpathway of chorismate metabolism (42/59 steps found)
- L-tyrosine degradation II (1/2 steps found)
- atromentin biosynthesis (1/2 steps found)
- superpathway of L-phenylalanine and L-tyrosine biosynthesis (3/5 steps found)
- L-phenylalanine degradation III (2/4 steps found)
- L-tyrosine biosynthesis II (2/4 steps found)
- L-tyrosine degradation III (2/4 steps found)
- L-tyrosine degradation IV (to 4-methylphenol) (1/3 steps found)
- superpathway of plastoquinol biosynthesis (2/5 steps found)
- L-phenylalanine degradation IV (mammalian, via side chain) (4/9 steps found)
- 4-hydroxybenzoate biosynthesis I (eukaryotes) (1/5 steps found)
- L-phenylalanine degradation VI (reductive Stickland reaction) (1/5 steps found)
- L-tyrosine degradation V (reductive Stickland reaction) (1/5 steps found)
- rosmarinic acid biosynthesis I (2/10 steps found)
- (S)-reticuline biosynthesis I (1/11 steps found)
- tropane alkaloids biosynthesis (1/11 steps found)
- superpathway of rosmarinic acid biosynthesis (3/14 steps found)
- superpathway of hyoscyamine (atropine) and scopolamine biosynthesis (4/16 steps found)
- anaerobic aromatic compound degradation (Thauera aromatica) (6/27 steps found)
KEGG Metabolic Maps
- Alkaloid biosynthesis I
- Alkaloid biosynthesis II
- Biosynthesis of alkaloids derived from histidine and purine
- Biosynthesis of alkaloids derived from ornithine, lysine and nicotinic acid
- Biosynthesis of alkaloids derived from shikimate pathway
- Biosynthesis of phenylpropanoids
- Histidine metabolism
- Lysine biosynthesis
- Methionine metabolism
- Novobiocin biosynthesis
- Phenylalanine metabolism
- Phenylalanine, tyrosine and tryptophan biosynthesis
- Tyrosine metabolism
Isozymes
Compare fitness of predicted isozymes for: 2.6.1.57, 2.6.1.9
Use Curated BLAST to search for 2.6.1.57 or 2.6.1.9
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (325 amino acids)
>GFF6304 Biosynthetic Aromatic amino acid aminotransferase beta (EC 2.6.1.57) (Variovorax sp. SCN45) MILLASNENPLGMPESARRAAAAALEGAGNYPDSNGTALKNALAARLDVPADWLTLGSGS SEILELAAQVSLKPGEGVVYSQYGFIVYGAATAHAHARATVVPAREYGHDLDAMRAAIGD DTKLVFVANPNNPTGTFIDAAPLLAFLQSVPAHVTVLLDEAYTEYLSPAQRYDSIEWVRR LPNLIVARTFSKAFGLAGLRIGYGVSQPALTARMNAHRPRFNVTTPAQAAAVAALGDADF LARTYELNTAGRDQLAAGFKELGLAFVPSSGNFLMVQVGDAQAVHARLLTAGIEVSLLGP YGLPQWLRVSIGLPEQNRAVLAALR