Protein Info for GFF626 in Variovorax sp. SCN45

Annotation: CzcABC family efflux RND transporter, transmembrane protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1042 transmembrane" amino acids 13 to 32 (20 residues), see Phobius details amino acids 332 to 352 (21 residues), see Phobius details amino acids 358 to 378 (21 residues), see Phobius details amino acids 385 to 409 (25 residues), see Phobius details amino acids 439 to 460 (22 residues), see Phobius details amino acids 470 to 494 (25 residues), see Phobius details amino acids 530 to 548 (19 residues), see Phobius details amino acids 871 to 890 (20 residues), see Phobius details amino acids 896 to 916 (21 residues), see Phobius details amino acids 923 to 944 (22 residues), see Phobius details amino acids 971 to 988 (18 residues), see Phobius details amino acids 1000 to 1024 (25 residues), see Phobius details TIGR00914: heavy metal efflux pump, CzcA family" amino acids 2 to 1027 (1026 residues), 980.9 bits, see alignment E=3.6e-299 PF00873: ACR_tran" amino acids 6 to 1021 (1016 residues), 844.3 bits, see alignment E=6.4e-258

Best Hits

KEGG orthology group: K07239, heavy-metal exporter, HME family (inferred from 81% identity to mms:mma_0286)

Predicted SEED Role

"Cobalt-zinc-cadmium resistance protein CzcA; Cation efflux system protein CusA"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1042 amino acids)

>GFF626 CzcABC family efflux RND transporter, transmembrane protein (Variovorax sp. SCN45)
VIDRLIAFSLTQRVFVMVLVAALVGFGAYALSNLPIEAFPDVQDVQVRVISQLPGQAPED
MERTVTLPIEREVSGIPKLSNVRSVTMTGLSIVTLTFADGTDDYFARQQVTEKLSTVTLP
TGVQPQLAPLSTAVGEVYRYTIEGGGLTDAQLRTLQDWTVRPFLRMTPGVADVVSFGGAI
TEYQVEVDPLALRKYQVTLDQLNQAIGNGNGSAGGGLMRQGDASLVVRSAGLFASLADIR
SVVIASRQGRAITVADVAEVRAGERPRFGIVAVDARDSVVEGIVSMTKGGNPAKINAELK
QRIGQLQAKLPPGVRIVPVYDRTELVRHTVSTVAENLVVGALLVIAVLIVFLSSWRAALI
VATVIPLALLFAFILMNARGVSANLISLGAVDFGIIIDSAVVIVEALMVRLAAKSVGDIA
SPEARHQRMGVLHRTLSDLAHPVLFSKAIIILAFVPIFTFQRVEGKIFTPVALTLSFALL
GAVLLTFTLLPTLLSYALQRGTLAEKHKPWLDWLQMRYRKLVMFTMRRGRVTLLLSAVPV
ALALLLAPRLGSEFLPKLDEGNIWLTVTLPTSAALETTKEVEHVVRAKLLAYPEVARVIA
QVGRPDDGSDPKGPNNLEILVDLKPREQWRFASKEDLVASMSAQLDGIPGISANFSQVIQ
DNVEEALSGFRGEIVAKIIGNNLDILDDKGAEVASVIKGIRGATDVDATRIGGQTEVVIT
PDRARLARYGMAINDVNTLVNQAMSGTSVTGFYDADKRFDVVVRVGDRHRNSVDAIAGLQ
LAVPGTQSGNGPGTIALGDVATIEVKQGASRIFRESGSRMVIVKVNLLGRDQGSFVEEAQ
RTVAEQVKLPPGYELTWGGQFENSQRAAKRLMVIVPLTALLIFSLLFWAFRSVRLAGLVL
GMIPFTLVGGLAALALADLHLSVSAAVGFIAVAGISVQNGVILVEEVTQRVRDGSAVARA
IVEGAAVRLRPILMTALMAGLGLLPAALSHGIGSETQRPFACVIVGGIVSGTLFTLLVLP
LAIGMFGNFYDETEEAAEPVPA