Protein Info for GFF622 in Xanthobacter sp. DMC5

Annotation: Signal peptidase I

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 transmembrane" amino acids 17 to 38 (22 residues), see Phobius details PF10502: Peptidase_S26" amino acids 14 to 222 (209 residues), 178.6 bits, see alignment E=5.1e-57 TIGR02227: signal peptidase I" amino acids 17 to 224 (208 residues), 168.7 bits, see alignment E=4.7e-54

Best Hits

KEGG orthology group: K03100, signal peptidase I [EC: 3.4.21.89] (inferred from 94% identity to xau:Xaut_3880)

Predicted SEED Role

"Signal peptidase I (EC 3.4.21.89)" in subsystem Signal peptidase (EC 3.4.21.89)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.4.21.89

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (250 amino acids)

>GFF622 Signal peptidase I (Xanthobacter sp. DMC5)
MTATSDSKKDGGFLETVRVIVHALLIALVIRTFLFQPFNIPSGSMKDTLLIGDYLFVSKY
SYGYSHFSIPFSPNLFSGRIFGSEPTRGDVVVFKLPKDNETDYIKRVVGMPGDKIQMING
LLHINGVPVQRERLSDVSEDDGSGRKVPVKRWRETLPNGVSYETLDLVDNGFYDNTPVYE
VPLGHFFMMGDNRDNSADSRVLSQVGYVPFENLIGKAQLIFFSIDEGASAWQVWTWPWTV
RWDRLFTRVH