Protein Info for GFF6204 in Variovorax sp. SCN45

Annotation: Diguanylate cyclase/phosphodiesterase domain 2 (EAL)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 590 PF00563: EAL" amino acids 17 to 240 (224 residues), 167.6 bits, see alignment E=3.1e-53 PF00990: GGDEF" amino acids 434 to 504 (71 residues), 35.7 bits, see alignment E=7.6e-13

Best Hits

Predicted SEED Role

No annotation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (590 amino acids)

>GFF6204 Diguanylate cyclase/phosphodiesterase domain 2 (EAL) (Variovorax sp. SCN45)
MPRHIRPSDTSSSHPPVSPFFQPIADLRQGTIFGHEALIRGPVGTPLHSPLELLALAARE
SRLTEFELHCVEVILAHWGQLNEPGRLFVNMSADALVAAMGGVGAACWLERMLAHHDVSA
RNVTVELTEQRAAGNPEALQHAVKALHALGARVALDDFGEGHSNLRRWKDLQPDFVKIDK
LLTQGIASCPQTVELVRTIVGLGHALGTELVAEGVEDAKDLRVLRDLGIAHGQGYLFGHP
APALQPLLPEAAAAAIRDTRIAVMPHASQPLQPNVLRNLSVIQAPALNPQTPIDEVSAIF
QKHPELHALAVVDQGWPVALINRRSLMNDYARMYFREVHGRRPCLSYGSVAPRIVEREDN
VESLLAILMSEDQRYLSEGFIVTEKKRYIGLGTGDQLVRAVTEARIEAARHANPLTFLPG
NIPINIHIARLLGSGADFVACYADLNNFKVFNDHYGYWRGDEMILLLARLATQHANPHRD
FVGHIGGDDFLVMFQSPDWHQRCTGLIDEFNRQASGLYDEAARQAGGVHGEDRHGVIRFT
PFATLSIGAVRIPPGMFRHAEDVASEAAIAKHEAKLAASGLTVREARPRA