Protein Info for GFF6200 in Variovorax sp. SCN45

Annotation: integral membrane sensor signal transduction histidine kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 489 transmembrane" amino acids 40 to 63 (24 residues), see Phobius details amino acids 193 to 217 (25 residues), see Phobius details PF00512: HisKA" amino acids 269 to 330 (62 residues), 31.8 bits, see alignment E=1.8e-11 PF02518: HATPase_c" amino acids 380 to 487 (108 residues), 91.5 bits, see alignment E=7.5e-30 PF13581: HATPase_c_2" amino acids 387 to 463 (77 residues), 28.5 bits, see alignment E=2e-10

Best Hits

KEGG orthology group: None (inferred from 49% identity to del:DelCs14_2839)

Predicted SEED Role

"Tricarboxylate transport sensor protein TctE"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (489 amino acids)

>GFF6200 integral membrane sensor signal transduction histidine kinase (Variovorax sp. SCN45)
MNPLPVENNAGPGASPGTRLGWGGALRRRCRRWMQPSLLRRLLLVQISVVGLLWTCTLGL
FLYDSNRFPELVRYDKIFACVISAAQNLAASPDRQQATLRAFDMALLETSGDFSSEVDKA
PVMQVWQRGKLIYNSSASVPPIINQTIGKVESIRLGDRSLRARTMISPVLDTRVMLAEPK
FLRLYFNVDHRSYYFLPLLISLPFLVFPAWLAVLLALRPWRQVTRETAERGPADLTPLSF
EPPHKELRPMVRSINGLLRSVRDRGARERGLIADAANELHTPLEAMRVNVEALKAQTNDR
GQRELMANLLRSNDRATRLVGQLQQLMRSDEMPQDAVPEPLALDALARERIALVGPLAHA
RGVRFDFAVEDGPVPVFGERESLISMLSNLIENAVKYSPDGGTVRVHVRREGTRAVLRVA
DEGPGIPPALRERVFDRFFRNPDQTQSGSGLGLAIVKSVLDKHHGRVVLGEGEDGRGLLA
TVWLPLPAG