Protein Info for GFF6182 in Variovorax sp. SCN45

Annotation: Chorismate mutase I (EC 5.4.99.5) / Prephenate dehydratase (EC 4.2.1.51)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01807: chorismate mutase
  • amino acids 19 to 92 (74 residues), 90 bits, E=4.8e-30
• PF01817: CM_2
  • amino acids 23 to 99 (77 residues), 73 bits, E=3.2e-24
• PF00800: PDT
  • amino acids 104 to 277 (174 residues), 192.7 bits, E=8.2e-61
• PF01842: ACT
  • amino acids 293 to 358 (66 residues), 37.8 bits, E=2e-13

Best Hits

KEGG orthology group: K14170, chorismate mutase / prephenate dehydratase [EC: 4.2.1.51 5.4.99.5] (inferred from 96% identity to vpe:Varpa_1779)

Predicted SEED Role

"Chorismate mutase I (EC 5.4.99.5) / Prephenate dehydratase (EC 4.2.1.51)" in subsystem Chorismate Synthesis or Phenylalanine and Tyrosine Branches from Chorismate (EC 4.2.1.51, EC 5.4.99.5)

MetaCyc Pathways

• superpathway of aromatic amino acid biosynthesis (18/18 steps found)
• superpathway of L-phenylalanine biosynthesis (10/10 steps found)
• superpathway of L-tyrosine biosynthesis (10/10 steps found)
• L-phenylalanine biosynthesis I (3/3 steps found)
• L-tyrosine biosynthesis I (3/3 steps found)
• L-phenylalanine biosynthesis III (cytosolic, plants) (2/2 steps found)
• L-phenylalanine biosynthesis II (3/4 steps found)
• L-tyrosine biosynthesis III (3/4 steps found)
• superpathway of chorismate metabolism (42/59 steps found)
• superpathway of L-phenylalanine and L-tyrosine biosynthesis (3/5 steps found)
• L-tyrosine biosynthesis II (2/4 steps found)
• bacilysin biosynthesis (1/10 steps found)
• salinosporamide A biosynthesis (4/15 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from shikimate pathway
• Biosynthesis of phenylpropanoids
• Phenylalanine, tyrosine and tryptophan biosynthesis

Isozymes

Compare fitness of predicted isozymes for: 4.2.1.51

Use Curated BLAST to search for 4.2.1.51 or 5.4.99.5

Protein Sequence (374 amino acids)

>GFF6182 Chorismate mutase I (EC 5.4.99.5) / Prephenate dehydratase (EC 4.2.1.51) (Variovorax sp. SCN45)
MTASAPTPPSSPSDNSESLADLRVQIDSLDQRLLSLLNERAHVAELVGEVKKREGTPFFR
PDRVAQVIDKMQKSNGGPLKDLHVAAIWREIMSACLALESPQRVAVLGPEGTFCEQAAID
YFGGAADLIYCASFDEVFHATAAGSAQYGVVGVENSTEGVVTRSLDLFLHSPTHVVGEVS
LLVRHHLLRSSNSLEGVEAVLAHPQALAQCQTWLSKHLPNAERRAVSSNAEGARLASTNP
AWAALAGERAATRFGLHIVAHAIQDDSYNRTRFSVICLPQTLAMPPASGRDCTSLIVSVP
NRPGAVHDLLVPLKANNVSMTRFESRPARTGQWEYYFYIDLDGHPSQPNVAAALAELRGL
CAFYKVLGAYPVKS