Protein Info for GFF6181 in Variovorax sp. SCN45

Annotation: Cyclohexadienyl dehydrogenase (EC 1.3.1.12)(EC 1.3.1.43)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 296 signal peptide" amino acids 1 to 21 (21 residues), see Phobius details PF03446: NAD_binding_2" amino acids 5 to 141 (137 residues), 35.4 bits, see alignment E=2.2e-12 PF03807: F420_oxidored" amino acids 5 to 95 (91 residues), 38 bits, see alignment E=4.3e-13 PF02153: PDH_N" amino acids 17 to 172 (156 residues), 130.9 bits, see alignment E=5.7e-42 PF20463: PDH_C" amino acids 177 to 271 (95 residues), 85.5 bits, see alignment E=5.6e-28

Best Hits

KEGG orthology group: K04517, prephenate dehydrogenase [EC: 1.3.1.12] (inferred from 88% identity to vpe:Varpa_1778)

Predicted SEED Role

"Cyclohexadienyl dehydrogenase (EC 1.3.1.12)(EC 1.3.1.43)" in subsystem Chorismate Synthesis or Phenylalanine and Tyrosine Branches from Chorismate (EC 1.3.1.12, EC 1.3.1.43)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.3.1.12 or 1.3.1.43

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (296 amino acids)

>GFF6181 Cyclohexadienyl dehydrogenase (EC 1.3.1.12)(EC 1.3.1.43) (Variovorax sp. SCN45)
MFEQLGLIGCGLMGGSFALALKRAKLVKRVVGYSKSPSTTERARQLGVIDVAAPSALLAV
SGADIVLLAVPVAASEATFKAIRHGIASETLVMDVGSTKGDVIEAARNGLQRQFANFVPA
HPIAGKELSGIEHAEASLFNGRQVVLTPVKTTLRSNVQRASQVWSGIGAHVVTMTHEEHD
AAFAAVSHLPHLLAFAYTNAIASQPQGDRFLSLAGPGFRDFSRIAASDPVMWRDVLLANR
QQVLEQSQAFRKALEDLETLMTAGDLQGLEQAIAAASKTRAAWKPATDTSSLQQDN