Protein Info for GFF6155 in Variovorax sp. SCN45

Annotation: Aerobic carbon monoxide dehydrogenase (quinone), large chain (EC 1.2.5.3)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 796 PF01315: Ald_Xan_dh_C" amino acids 26 to 145 (120 residues), 99.1 bits, see alignment E=2.9e-32 PF02738: MoCoBD_1" amino acids 162 to 411 (250 residues), 245.7 bits, see alignment E=5.7e-77 PF20256: MoCoBD_2" amino acids 441 to 726 (286 residues), 316.6 bits, see alignment E=2.6e-98

Best Hits

KEGG orthology group: None (inferred from 97% identity to vap:Vapar_1594)

Predicted SEED Role

"Carbon-monoxide dehydrogenase form II, large subunit (EC 1.2.99.2)" in subsystem CO Dehydrogenase (EC 1.2.99.2)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.2.99.2

Use Curated BLAST to search for 1.2.99.2

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (796 amino acids)

>GFF6155 Aerobic carbon monoxide dehydrogenase (quinone), large chain (EC 1.2.5.3) (Variovorax sp. SCN45)
MGASDFSNLPHIGEALRRKEDYRFLTGAGNYTDDITLANQSHAVFVRSPHAHATVKSVDI
AEAMKMPGVVGIFSGKDIEGKMGGLPCGWLINNPDGTPMKEPMHPILAINKVRYVGDHVA
MVVAETVEQARNAAEAVVVDYDVLPALVSVADAAKKAGGVTLHDEAPDNQCYKWALGDKA
AVDAAFANAAHVTKLDLVNNRLVPNPIEPRVAIGSYSRGTDDYTLYVSNQNPHVERLLMT
AFVLGLPEHKVRVIAPDVGGGFGSKIFLYAEDVCLTWAAKQLNRNIKWTAERSECFLSDA
HGRDHVSHAEMAMDKDGKFLAMRVHTDANLGAYLSTFATAVPTILYATLLAGQYTTPQIY
VEVDAWFTNTAPVDAYRGAGRPEATYLLERLVSRCAWEMNLGQDEIRKRNFISTFPYQTP
VALQYDTGDFHACMDKARVLAEVDGYAARKAASEAGGKLRGMGYSSYIEACGIAPSNIAG
ALGARAGLFECGEIRVHPTGSVTVFTGSHSHGQGHETTFAQVVAARLGIPVENVDVVHGD
TGRVPFGMGTYGSRSISVGGAAIMKALDKIETKAKKIAAHLMEASDADIEFANGEFTVKG
TDKKIPFGQVALTAYVPHNYPLDKLEPGLNETAFYDPTNFTFPGGTYICEVEIDRQTGEV
RVDRFTAVDDFGTIINPMIVEGQVHGGLVQGIGQALLENCVYDRETGQLLTGSFMDYAMP
RAAEFPQFKLDTVCTPCTHNPLGTKGCGEAGAIGSPPAVINAVLDALAPLGVKDFDMPAS
SSRVWEAMQAASGANH