Protein Info for GFF6036 in Variovorax sp. SCN45

Annotation: DNA translocase FtsK

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 815 transmembrane" amino acids 30 to 51 (22 residues), see Phobius details amino acids 81 to 100 (20 residues), see Phobius details amino acids 130 to 149 (20 residues), see Phobius details amino acids 178 to 202 (25 residues), see Phobius details PF13491: FtsK_4TM" amino acids 25 to 212 (188 residues), 137.6 bits, see alignment E=7.1e-44 PF17854: FtsK_alpha" amino acids 325 to 425 (101 residues), 107.3 bits, see alignment E=8.3e-35 PF01580: FtsK_SpoIIIE" amino acids 433 to 642 (210 residues), 245.7 bits, see alignment E=7.6e-77 PF09397: FtsK_gamma" amino acids 749 to 809 (61 residues), 94.3 bits, see alignment 5.9e-31

Best Hits

KEGG orthology group: K03466, DNA segregation ATPase FtsK/SpoIIIE, S-DNA-T family (inferred from 92% identity to vpe:Varpa_1386)

Predicted SEED Role

"Cell division protein FtsK" in subsystem Bacterial Cell Division or Bacterial Cytoskeleton or Bacterial RNA-metabolizing Zn-dependent hydrolases

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (815 amino acids)

>GFF6036 DNA translocase FtsK (Variovorax sp. SCN45)
MTYSLNTLQSSSAADGQPVRTRAMRFAHEITLIAGFAALLFWLLAMLSFTLSDAAWSTSG
TGGEIKNWGGRVGAWLADGSYFVAGYSVWWCLAAGLRAWLSSLASWLRGGEPASTAEQQP
PRGRFNRSRLAFWLGLVLLLCASAMLEWSRLYRLEGHLPGGAGGGAIGALVGPSSVRWLG
FTGSALVAIAGGVIGSALVFRFSWSLIAERIGARAYSLFESRREKREMAADIAMGKQAAR
ERAEADEPAFTRGGEASGRGGEPSMSSAPSAFEDDDEIRIEPRAKRRPPSPPVQIEPAMT
EVPKSDRVVKERQKPLFKELPDSKLPQVDLLDAAQARQETVSSDTLEMTSRMIEKKLKDF
GVEVRVVLASPGPVITRYEIEPATGVKGSQIVNLAKDLARSLSLVSIRVVETIPGKNYMA
LELPNAKRQSIKLSEILGSQIYNEGKSMLTMGLGKDIIGNPVVADLAKMPHVLVAGTTGS
GKSVGINAMILSLLYKAEARDVRLLMIDPKMLEMSVYEGIPHLLAPVVTDMRQAAHGLNW
CVAEMERRYKLMSKLGVRNLAGYNTKIDEAKAREEFIYNPFSLTPDDPEPLKREPHIVVV
IDELADLMMVVGKKIEELIARLAQKARAAGIHLILATQRPSVDVITGLIKANIPTRIAFQ
VSSKIDSRTILDQMGAEALLGMGDMLYMPSGTGLPVRVHGAFVSDEEVHRVVAYLKSQGE
PDYIEGVLEGGTVDGDGDGDMLGGGGDAEKDPMYDQAVEVVLKNRKASISLVQRHLKIGY
NRAARLVEDMEKAGLVSAMSGSGQREILVPARAAE