Protein Info for GFF601 in Hydrogenophaga sp. GW460-11-11-14-LB1

Annotation: Transcriptional regulator, IclR family

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 253 PF09339: HTH_IclR" amino acids 12 to 60 (49 residues), 55 bits, see alignment 8.6e-19 PF01614: IclR" amino acids 126 to 250 (125 residues), 101.1 bits, see alignment E=6.5e-33

Best Hits

Swiss-Prot: 42% identical to SAUR_CUPNH: Probable transcriptional regulator SauR (sauR) from Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337)

KEGG orthology group: None (inferred from 53% identity to ctt:CtCNB1_3805)

Predicted SEED Role

"Transcriptional regulator, IclR family" in subsystem Homogentisate pathway of aromatic compound degradation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (253 amino acids)

>GFF601 Transcriptional regulator, IclR family (Hydrogenophaga sp. GW460-11-11-14-LB1)
MNTETDSSPGLRLLELLDLLTRHAQPLALPEVVTLTGWPKPTVHRMLSQLEQGGWLVREP
DGRRYAMATRLLRLAEAALSNSTQQGVRHAVLRQLVAEVGESCNLTALSGAEVVYLDRVE
SAFPLRLELRPGTRVPAHCSASGKLFLAWMGARQRRAVLDGLVLTRYTAHTLTQREALEA
ELEAIRRDGHAVDAEEFVEGLVCVAVPVFAPGQRTVRCALALQAPAARMALAQARLQLPR
LEAAAQALARTLG