Protein Info for GFF599 in Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868

Annotation: Transcriptional activator of maltose regulon, MalT

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 901 PF17874: TPR_MalT" amino acids 449 to 782 (334 residues), 357.3 bits, see alignment E=9.4e-111 PF00196: GerE" amino acids 835 to 890 (56 residues), 70.9 bits, see alignment 5.5e-24

Best Hits

Swiss-Prot: 100% identical to MALT_SALA4: HTH-type transcriptional regulator MalT (malT) from Salmonella agona (strain SL483)

KEGG orthology group: K03556, LuxR family transcriptional regulator, maltose regulon positive regulatory protein (inferred from 91% identity to eco:b3418)

MetaCyc: 91% identical to DNA-binding transcriptional activator MalT (Escherichia coli K-12 substr. MG1655)

Predicted SEED Role

"Transcriptional activator of maltose regulon, MalT" in subsystem Maltose and Maltodextrin Utilization

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (901 amino acids)

>GFF599 Transcriptional activator of maltose regulon, MalT (Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868)
MLIPSKLSRPVRLDHTVVRERLLAKLSGANNFRLALVTSPAGYGKTTLVSQWAAGKNELG
WYSLDEGDNQQERFASYLIAAIQQATGGHCSTSEAMAQKRQYASLTSLFAQLFIELAQWH
RPLYLVIDDYHLITNPVIHDAMRFFLRHQPENFTLVVLSRNLPQLGIANLRVRDQLLEIG
SQQLAFNHQEAKQFFDRRLSSPIEAAESSRMCDDVAGWATALQLIALSARQNHTSAHHSA
RRLAGINASHLSDYLVDEVLDNVDVSTRHFLLKSAILRSMNDALIVRVTGEENGQMRLEE
IERQGLFLQRMDDTGEWFSYHPLFGSFLRQRCQWELAAELPEIHRAAAESWMEQGFPSEA
IHHALAAGDAQMLRDILLNHAWGLFNHSELALLEESLKALPWESLLENPRLVLLQAWLMQ
SQHRYSEVNTLLARAEQEIKGVMDGTLHAEFNALRAQVAINDGNPEEAERLAKLALDELP
LAWFYSRIVATSVHGEVLHCKGDLSQSLSLMQQTEQMARHHDVWHYALWSLIQQSEIQFA
QGFLQAAWETQERAFQLIKEQHLEQLPMHEFLVRIRAQLLWAWARLDEAEASARSGIAVL
STFQPQQQLQCLTLLVQCSLARGDLDNARSQLNRLENLLGNGRYHCDWISNADKVRVIYW
QLTGDKKSAANWLRHTPKPAFANNHFLQGQWRNIARAQILLGEFEPAEIVLEELNENARS
LRLMSDLNCNLLLLNQLYWQSGRKNDAQRVLLDALQLANRTGFISHFVIEGEAMAQQLRQ
LIQLNTLPEMEQHRAQRILREINQHHRHKFAHFDEGFVERLLNHPDVPELIRTSPLTQRE
WQVLGLIYSGYSNEQIAGELAVAATTIKTHIRNLYQKLGVAHRQDAVQHAQQLLKMMGYG
V