Protein Info for GFF5980 in Variovorax sp. SCN45

Annotation: Cyanate hydratase (EC 4.2.1.104)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF21291: CYNS_N
  • amino acids 3 to 71 (69 residues), 98.9 bits, E=1.3e-32
• TIGR00673: cyanase
  • amino acids 4 to 147 (144 residues), 172.5 bits, E=3e-55
• PF02560: Cyanate_lyase
  • amino acids 80 to 145 (66 residues), 122.4 bits, E=5.3e-40

Best Hits

Swiss-Prot: 99% identical to CYNS_VARPS: Cyanate hydratase (cynS) from Variovorax paradoxus (strain S110)

KEGG orthology group: K01725, cyanate lyase [EC: 4.2.1.104] (inferred from 97% identity to vpe:Varpa_1447)

MetaCyc: 42% identical to cyanase (Escherichia coli K-12 substr. MG1655)
Cyanase. [EC: 4.2.1.104]

Predicted SEED Role

"Cyanate hydratase (EC 4.2.1.104)" in subsystem Cyanate hydrolysis (EC 4.2.1.104)

MetaCyc Pathways

• uracil degradation III (5/5 steps found)
• L-citrulline degradation (3/3 steps found)
• cyanate degradation (3/3 steps found)
• urea degradation I (3/3 steps found)
• L-arginine degradation V (arginine deiminase pathway) (3/4 steps found)
• cyanuric acid degradation II (3/5 steps found)
• superpathway of allantoin degradation in yeast (3/6 steps found)
• cyanuric acid degradation I (2/5 steps found)
• superpathway of atrazine degradation (3/8 steps found)
• allantoin degradation IV (anaerobic) (2/9 steps found)

KEGG Metabolic Maps

• Nitrogen metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.2.1.104

Protein Sequence (147 amino acids)

>GFF5980 Cyanate hydratase (EC 4.2.1.104) (Variovorax sp. SCN45)
MNRNDVTEKIITVKVSKGIQWADVAKKVGLSKEWTTAACLGQMTLDDKQAKVVGKIFGLT
PEEQKWLQVVPYKGSLPTPVPTDPLIYRWYEVVSVYGTTIKELIHEEFGDGIMSAIDFSM
DIQRQADPKGDRVNVVLSGKFLPYKTY