Protein Info for GFF5957 in Variovorax sp. SCN45

Annotation: Uncharacterized MFS-type transporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 441 transmembrane" amino acids 38 to 59 (22 residues), see Phobius details amino acids 66 to 87 (22 residues), see Phobius details amino acids 98 to 120 (23 residues), see Phobius details amino acids 126 to 126 (1 residues), see Phobius details amino acids 129 to 153 (25 residues), see Phobius details amino acids 172 to 193 (22 residues), see Phobius details amino acids 199 to 218 (20 residues), see Phobius details amino acids 265 to 282 (18 residues), see Phobius details amino acids 288 to 307 (20 residues), see Phobius details amino acids 319 to 337 (19 residues), see Phobius details amino acids 343 to 362 (20 residues), see Phobius details amino acids 382 to 404 (23 residues), see Phobius details amino acids 410 to 431 (22 residues), see Phobius details PF00083: Sugar_tr" amino acids 29 to 243 (215 residues), 76.4 bits, see alignment E=3.4e-25 amino acids 232 to 440 (209 residues), 44.2 bits, see alignment E=2e-15 PF07690: MFS_1" amino acids 60 to 298 (239 residues), 73.9 bits, see alignment E=1.8e-24 amino acids 268 to 434 (167 residues), 44.7 bits, see alignment E=1.3e-15 PF13347: MFS_2" amino acids 67 to 367 (301 residues), 33.7 bits, see alignment E=2.3e-12

Best Hits

KEGG orthology group: None (inferred from 90% identity to vpe:Varpa_1471)

Predicted SEED Role

"L-Proline/Glycine betaine transporter ProP" in subsystem Proline, 4-hydroxyproline uptake and utilization

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (441 amino acids)

>GFF5957 Uncharacterized MFS-type transporter (Variovorax sp. SCN45)
MTEHVLPSPATAGAAPAAPPPKMGRLAMASSIGTTLEWYDFTVYNIMAALVFNAVFFPSF
DPLTGTILAFSTYAVGYISRPLGGVVFGHLGDRLGRRFVLVATLVIMGVSTGLMGLLPTY
ATWGIWAPVTLVALRFVQGVALGGEWAGAVLLSMEHGKPDERGRNASFTQVGPSCGTLIG
TGFIAIVSAWLSPEDFQSWGWRIPFISSVALVLFGLWLRRGVDETPVFREMEERKATAKT
PIKEVFTQHWRSLLVAGGSRIGSDVLYALVVVFTLTYVTTVLHLSRPLALTATMIGAACN
AVAVPWFGSLSDRIGRRPVYIAGALLGMVWAFVFFVLMDSAHPIAICAAVVVGLLIHAMM
YGPQAAFVTEQFPGRVRYAGASLAYTLAGILGGGFAPLIIASLFKSWGSTAAVSLYVVAA
LGVTLIALLVARETAKRPLES