Protein Info for GFF594 in Variovorax sp. SCN45

Annotation: ABC transporter, substrate-binding protein (cluster 4, leucine/isoleucine/valine/benzoate)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 373 PF13458: Peripla_BP_6" amino acids 29 to 366 (338 residues), 164.8 bits, see alignment E=6.7e-52 PF13433: Peripla_BP_5" amino acids 35 to 251 (217 residues), 30.5 bits, see alignment E=3.1e-11 PF01094: ANF_receptor" amino acids 51 to 322 (272 residues), 69.5 bits, see alignment E=4.1e-23

Best Hits

KEGG orthology group: None (inferred from 93% identity to vpe:Varpa_3552)

Predicted SEED Role

"Extracellular ligand-binding receptor"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (373 amino acids)

>GFF594 ABC transporter, substrate-binding protein (cluster 4, leucine/isoleucine/valine/benzoate) (Variovorax sp. SCN45)
MGIAAHPAWAQQAARPAAAAAGAARVVLLGQSVPLTGGASEIGSAFAAGSRLAVSDFNER
NAATGLQLKLLQLDDGYDAARATTNARTLLTTNKADMLFGFVGTASSEAGANVATQQGSL
LFAPFAASDTLRGADHPNVFHVRPGMIDEALKIVRQCATVGQTRIALVGDDDAMGRAGLA
AVQQAASELKLPPLVATALVPANGDKLDAALKTVQQQSPQAIVLVSLSGTTANAIRKLRK
SGYTGNFMAFSIVGIDPLYATLGKDIGGIVISQVVPSPRPSAIPIVKEYLAAVDNSDQTA
SYEGLEGFIAAKAAGEAVRRAGKGFNTASLQRVMTGMTDYDVGGFRINLRPGLRDNVRSI
DLISISSDGRVLR