Protein Info for GFF584 in Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868
Annotation: Glycerol dehydrogenase (EC 1.1.1.6)
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 65% identical to GLDA_THEMA: Glycerol dehydrogenase (gldA) from Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
KEGG orthology group: K00005, glycerol dehydrogenase [EC: 1.1.1.6] (inferred from 100% identity to seh:SeHA_C3838)MetaCyc: 53% identical to glycerol dehydrogenase subunit (Citrobacter freundii)
Glycerol dehydrogenase. [EC: 1.1.1.6]
Predicted SEED Role
"Glycerol dehydrogenase (EC 1.1.1.6)" in subsystem Respiratory dehydrogenases 1 (EC 1.1.1.6)
MetaCyc Pathways
- glycerol degradation II (1/2 steps found)
- glycerol degradation V (1/2 steps found)
- glycerol degradation to butanol (11/16 steps found)
- superpathway of glycerol degradation to 1,3-propanediol (1/4 steps found)
KEGG Metabolic Maps
Isozymes
Compare fitness of predicted isozymes for: 1.1.1.6
Use Curated BLAST to search for 1.1.1.6
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Compare to protein structures
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (369 amino acids)
>GFF584 Glycerol dehydrogenase (EC 1.1.1.6) (Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868) MVTTAIFPSRYVQGKGALTTHLPQELAALGHKALILQDPVVHNTYRDTVATALHGVIEFD IEVFSSECCDEEIARISARAQEIGADVIVGMGGGKTLDTAKATGASLRLPIAVVPTLAST DAPCSSLVVIYTPEGKFKRYLMIPRNPTLVLVDSSIIAAAPVRFLVSGIGDALATWFEAE DCRIKGAGNMTTRPGPMTAFELARFCYTTLMRYGRLAKLACEQHQVTPALEHVIEANTLL SGLGFESGGLAAAHAIHNGLTVLPATHKYWHGEKVAFGTLAMLMLTDRAPELIEEVYQFC EDIGLPTTLADIGLAGVSDDELLAVARASCQTGETIHNEPFTITPEAVQAALRAADAVGQ ARKKIDLAG