Protein Info for GFF5767 in Hydrogenophaga sp. GW460-11-11-14-LB1

Annotation: Lipid IVA 3-deoxy-D-manno-octulosonic acid transferase (EC 2.4.99.12) [often with (EC 2.4.99.13) also]

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF04413: Glycos_transf_N
  • amino acids 46 to 223 (178 residues), 200.5 bits, E=2.5e-63
• PF06293: Kdo
  • amino acids 475 to 669 (195 residues), 134.4 bits, E=5.8e-43
• PF01163: RIO1
  • amino acids 519 to 622 (104 residues), 22.9 bits, E=8.7e-09

Predicted SEED Role

"Lipid IVA 3-deoxy-D-manno-octulosonic acid transferase (EC 2.4.99.12) [often with (EC 2.4.99.13) also]" (EC 2.4.99.12, EC 2.4.99.13)

MetaCyc Pathways

• superpathway of (Kdo)₂-lipid A biosynthesis (14/17 steps found)
• Kdo transfer to lipid IV_A (Brucella) (2/2 steps found)
• Kdo transfer to lipid IV_A (E. coli) (2/2 steps found)
• Kdo transfer to lipid IV_A (H. pylori) (2/2 steps found)
• Kdo transfer to lipid IV_A (P. gingivalis) (2/2 steps found)
• Kdo transfer to lipid IV_A (P. putida) (2/2 steps found)
• Kdo transfer to lipid IV_A (generic) (2/2 steps found)
• Kdo transfer to lipid IV_A (Haemophilus) (1/2 steps found)
• Kdo transfer to lipid IV_A (Vibrio cholerae serogroup O1 El Tor) (1/2 steps found)
• Kdo transfer to lipid IV_A (Chlamydia) (2/5 steps found)
• superpathway of Kdo₂-lipid A biosynthesis (14/25 steps found)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.4.99.12 or 2.4.99.13

Protein Sequence (676 amino acids)

>GFF5767 Lipid IVA 3-deoxy-D-manno-octulosonic acid transferase (EC 2.4.99.12) [often with (EC 2.4.99.13) also] (Hydrogenophaga sp. GW460-11-11-14-LB1)
MGRRPLALSPVSLPHRAYRLLSRALAAPLLGWLWWRGRREPGYRQNLRHRLGFIPVDPEQ
LGCIWVHAASVGEVQAMQPLLHALLEEWPAHAVVVSTQTPTGARALQAHWGDQIRHVYAP
IDTPGAVARFLNRLQPRLLILVERELWPEWLLQCRAHAIPVALVNARLSEGSARTYRRWP
GLMRPVWPQLTVAAADTASAQRLRELGVPPARLHETGNLKFDVAVPAARVALPPELQERT
LVVAGSTHEGDEVAWLAIWRELAPVNPSWLLVLVPRHPQRFDEVADHLQHSGLAFVRRSS
GQVVAPGTQVLLVDAMGELMHWYQHASLCFVGGTLAPVGGHNPLEPMSVGQPVLFGPHVH
NAAPLFEEIARSGAGECVRSARELAAAVQRWLVQPETWQRRADAARELIARNRGASARTL
AVVRPLWQPAQTDNISHVRTAVSAGRTCWFDPHHLSQVSAHHFDPIAHVGGTALATGSGR
GQAMLVHEGEHAYVLRHYRRGGLMARLSHDRFWRAAPHDSRAMREFTLLRLMRSWQLPVP
EPVAASHWPRAGLFYEADILVGLIPGSANVVQALQRRSLAPADWQALGRAIRQLHDRQVF
HSDLNAHNLLLDRTGQAWVVDFDKCEVRTGDDWKPKNLARLLRSLRKEATRVTPYHWAEA
DWALLMAGYEGPATAP