Protein Info for GFF5759 in Hydrogenophaga sp. GW460-11-11-14-LB1

Annotation: Glutaryl-CoA dehydrogenase (EC 1.3.99.7)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF02771: Acyl-CoA_dh_N
  • amino acids 21 to 133 (113 residues), 126.5 bits, E=1.3e-40
• PF02770: Acyl-CoA_dh_M
  • amino acids 137 to 228 (92 residues), 76.5 bits, E=2.9e-25
• PF00441: Acyl-CoA_dh_1
  • amino acids 241 to 387 (147 residues), 102.4 bits, E=5.4e-33

Best Hits

Swiss-Prot: 66% identical to GCDH_BOVIN: Glutaryl-CoA dehydrogenase, mitochondrial (GCDH) from Bos taurus

KEGG orthology group: K00252, glutaryl-CoA dehydrogenase [EC: 1.3.99.7] (inferred from 87% identity to lch:Lcho_1193)

MetaCyc: 85% identical to glutaryl-CoA dehydrogenase (Pseudomonas putida KT2440)
GLUTARYL-COA-DEHYDROGENASE-RXN [EC: 1.3.8.6]

Predicted SEED Role

"Glutaryl-CoA dehydrogenase (EC 1.3.99.7)" (EC 1.3.99.7)

MetaCyc Pathways

• glutaryl-CoA degradation (3/5 steps found)
• L-tryptophan degradation III (eukaryotic) (7/15 steps found)
• benzoate fermentation (to acetate and cyclohexane carboxylate) (6/17 steps found)
• crotonate fermentation (to acetate and cyclohexane carboxylate) (5/16 steps found)
• toluene degradation VI (anaerobic) (4/18 steps found)

KEGG Metabolic Maps

• Benzoate degradation via CoA ligation
• Fatty acid metabolism
• Lysine degradation
• Tryptophan metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.3.8.6 or 1.3.99.7

Protein Sequence (394 amino acids)

>GFF5759 Glutaryl-CoA dehydrogenase (EC 1.3.99.7) (Hydrogenophaga sp. GW460-11-11-14-LB1)
MTPTKARFSWEDPFQLDQQLSDDERQVRDAAHSYCQEKLLPRVTEAFRHEKTDAAIFREM
GSLGLLGPTIPEAYGGSGLNYVCYGLVAREVERVDSGYRSMMSVQSSLVMVPINEFGSEA
QKQKYLPKLATGEWIGCFGLTEPNHGSDPGSMVTRAKKVAGGYSLSGAKMWITNSPIADV
FVVWAKDDEGSIRGFILEKGMKGLSAPAIHSKVGLRASVTGEIVLDEVFCPEENAFPEVR
GLKGPFTCLNSARYGIAWGALGAAEDCYFRARQYVLDRQQFGRPLAANQLIQKKLADMLT
EISLGLQGCLRLGRMKDEGTAAVEITSILKRNSCGKALDIARLARDMMGGNGISDEFGVA
RHLVNLEVVNTYEGTHDIHALILGRAITGIQAFS