Protein Info for GFF5685 in Hydrogenophaga sp. GW460-11-11-14-LB1

Annotation: RND efflux system, inner membrane transporter CmeB

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1060 transmembrane" amino acids 12 to 32 (21 residues), see Phobius details amino acids 340 to 359 (20 residues), see Phobius details amino acids 366 to 388 (23 residues), see Phobius details amino acids 394 to 413 (20 residues), see Phobius details amino acids 438 to 459 (22 residues), see Phobius details amino acids 470 to 494 (25 residues), see Phobius details amino acids 549 to 567 (19 residues), see Phobius details amino acids 876 to 894 (19 residues), see Phobius details amino acids 901 to 921 (21 residues), see Phobius details amino acids 927 to 952 (26 residues), see Phobius details amino acids 973 to 992 (20 residues), see Phobius details amino acids 1004 to 1030 (27 residues), see Phobius details PF00873: ACR_tran" amino acids 1 to 1031 (1031 residues), 1212.1 bits, see alignment E=0 TIGR00915: RND transporter, hydrophobe/amphiphile efflux-1 (HAE1) family" amino acids 1 to 1043 (1043 residues), 1462.3 bits, see alignment E=0 PF03176: MMPL" amino acids 333 to 496 (164 residues), 35.7 bits, see alignment E=4.8e-13

Best Hits

KEGG orthology group: K03296, hydrophobic/amphiphilic exporter-1 (mainly G- bacteria), HAE1 family (inferred from 75% identity to adn:Alide_2389)

Predicted SEED Role

"RND efflux system, inner membrane transporter CmeB" in subsystem Multidrug Resistance Efflux Pumps or Multidrug efflux pump in Campylobacter jejuni (CmeABC operon)

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1060 amino acids)

>GFF5685 RND efflux system, inner membrane transporter CmeB (Hydrogenophaga sp. GW460-11-11-14-LB1)
MAHFFIHRPVFAWVLSIVVMLAGFMSIFTLPLEQYPDIAPPRVSINTIYTGASAETVADS
VTQVIEQQLKGIDNVLYMSSTSDSAGRSRTQLTFAPGTDIDVAQVQVQNKLQTAMNRLPE
AVKSRGVFVNKGGQDNLMTYVFTSPDPTVTQVAIGDYITSNVVDVISRIDGVGDVSVFGT
SYAMRIWMDPGKLEQYALMPSDIVSALNSQNAQVSAGQLGALPAVKDQMLNATITARTKL
KTVDEFRGIVLKAAADGSLVTVGDVARVELDADNLTVKSRLNNQPGAGLGIVLADGANAM
AVANAVNAKMAELAPFFPDGITGVISSDTTPYVRASIKEVAVTLAEAMVLVVIVMFIFLQ
NLRATLIPAIAVPVVLLGTFGVLSVLGYSINMLTMFAMVLAIGLLVDDAIVVVENVERVM
HQEGLPAKEATIKSMAEITPALVGIGLTLSAVFIPMAFFSGSVGVIYRQFSIAIVSAMAF
SVLVALSLTPALCATILKPTEHLHEGAPARKGLLGWVDRFFRWFNAGFDRNSGRYQGAVR
QLLLRSKRVMLLFVMVVGGVVFLFQKLPTSFLPVEDQGFITASVTLPAGSSDAQLEVVLQ
DITRYFNAQPDVLRVNSLAGNSGNQSSGTIFVRLKPWDERPNPEQSAEAISRKATRDLSR
IRAARIFVSMPPAVRGLGSDAGVNFMLKDINGLGNDALRAAKDRVVELAGQHPELTNMRT
TDFDVTSELKVVIDDRKAAALGLSTSDINNVLSSAVGGSYVNDFVHNGRVKRVYVQGDAP
YRMLPQDIGKWTVRNRSGEMVPLAAFTTTTWTSSAPQLLRYNGSPAMEMIANTAPGVSSG
AAMRAVEDIMAQMPVGIGYEWTGASLQERQSGAQAPLLYAISILFVFLCLAALYESWSVP
FSVILAVPLGIVGALLATYFRGMSNDVYFQVGLLTTVGLASKNAILIVEFAVQLQDQGRS
IFDATLEAVRRRLRPILMTSLAFGFGVLPLALGTGPGAASRQAIGTAVLGGTVLSTALGL
FFVPVFFLLVRSWVQRRRSKDTPAPVAPLATPSLSHQGEA