Protein Info for GFF568 in Variovorax sp. SCN45

Annotation: Diaminohydroxyphosphoribosylaminopyrimidine deaminase (EC 3.5.4.26) / 5-amino-6-(5-phosphoribosylamino)uracil reductase (EC 1.1.1.193)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 365 PF00383: dCMP_cyt_deam_1" amino acids 1 to 97 (97 residues), 68.5 bits, see alignment E=6e-23 TIGR00326: riboflavin biosynthesis protein RibD" amino acids 1 to 354 (354 residues), 355.1 bits, see alignment E=4.3e-110 PF14437: MafB19-deam" amino acids 3 to 114 (112 residues), 37.5 bits, see alignment E=3.2e-13 TIGR00227: riboflavin-specific deaminase C-terminal domain" amino acids 144 to 358 (215 residues), 176.4 bits, see alignment E=5.9e-56 PF01872: RibD_C" amino acids 145 to 320 (176 residues), 156.5 bits, see alignment E=1.2e-49

Best Hits

KEGG orthology group: K11752, diaminohydroxyphosphoribosylaminopyrimidine deaminase / 5-amino-6-(5-phosphoribosylamino)uracil reductase [EC: 1.1.1.193 3.5.4.26] (inferred from 86% identity to vpe:Varpa_3522)

Predicted SEED Role

"Diaminohydroxyphosphoribosylaminopyrimidine deaminase (EC 3.5.4.26) / 5-amino-6-(5-phosphoribosylamino)uracil reductase (EC 1.1.1.193)" in subsystem Riboflavin, FMN and FAD metabolism (EC 1.1.1.193, EC 3.5.4.26)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.193 or 3.5.4.26

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (365 amino acids)

>GFF568 Diaminohydroxyphosphoribosylaminopyrimidine deaminase (EC 3.5.4.26) / 5-amino-6-(5-phosphoribosylamino)uracil reductase (EC 1.1.1.193) (Variovorax sp. SCN45)
MTQALNLARQAGPETDPNPRVGCVLVATNGTVIGQGHTQQVGGPHAEVMALRDAAARGNS
VVGATAWVTLEPCAHHGRTGPCCDALIAAGVSRVVAALTDPNPLVAGQGFERLRAAGIEV
EVGPGAQEARELNIGFLSRMVRKTPWVRMKVAASLDGKTGLENGVSQWITSQAARTDGHA
WRARASAVLTGVGTVLEDNPRLDVRLVQTPRQPHLVVVDSRLQTPPDAHIFIEGRAVWIY
AAHRDEEKAKALEARGATVTCLPDANGKVDLGAMLKDLAARGVNELHVESGHKLNGSLLR
EGCVDELLVYLAPKLIGSGLDIASHLHADGPLTSLTGALPLEFKSVDMLGPDLRIVARVA
GRDAF