Protein Info for GFF5642 in Variovorax sp. SCN45

Annotation: Sulfur carrier protein FdhD

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00129: formate dehydrogenase family accessory protein FdhD
  • amino acids 41 to 292 (252 residues), 187.1 bits, E=1.7e-59
• PF02634: FdhD-NarQ
  • amino acids 46 to 291 (246 residues), 205.9 bits, E=4.2e-65

Best Hits

Swiss-Prot: 51% identical to FDHD_BURCJ: Sulfur carrier protein FdhD (fdhD) from Burkholderia cenocepacia (strain ATCC BAA-245 / DSM 16553 / LMG 16656 / NCTC 13227 / J2315 / CF5610)

KEGG orthology group: K02379, FdhD protein (inferred from 87% identity to vpe:Varpa_4732)

Predicted SEED Role

"Formate dehydrogenase chain D (EC 1.2.1.2)" in subsystem Formate hydrogenase (EC 1.2.1.2)

MetaCyc Pathways

• formate oxidation to CO₂ (1/1 steps found)
• purine nucleobases degradation II (anaerobic) (16/24 steps found)
• oxalate degradation VI (1/4 steps found)
• oxalate degradation III (1/5 steps found)
• superpathway of C1 compounds oxidation to CO₂ (4/12 steps found)
• purine nucleobases degradation I (anaerobic) (6/15 steps found)

KEGG Metabolic Maps

• Glyoxylate and dicarboxylate metabolism
• Methane metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.2.1.2

Use Curated BLAST to search for 1.2.1.2

Protein Sequence (297 amino acids)

>GFF5642 Sulfur carrier protein FdhD (Variovorax sp. SCN45)
MAAAMQDDPTITESDSLPPLARHAVHVFGERGLAPEGVVRDDTLASEVPVALVFNGVSHA
VMMATPQDLEAFALGFALSEGILDSAADCRGIDVRTVDASDAGLPEGMPGIEVQLEISTR
SFERLKDRRRSLAGRTGCGVCGVESFAGLDLTPQRVPQRDWIERIDLATVLRAFAAMPPR
QTLNAEAGAIHAAAWATVDGELTDLMEDVGRHNALDKLLGKLAMAGRLEEPGFVLMSSRG
SHELVRKCARLGIAAMATISAPTSMGVRMAELCGLRFWGLCRAPRGVLYAGGLNHGN