Protein Info for GFF5595 in Hydrogenophaga sp. GW460-11-11-14-LB1

Annotation: Phosphatidylserine decarboxylase (EC 4.1.1.65)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00163: phosphatidylserine decarboxylase
  • amino acids 64 to 290 (227 residues), 142.1 bits, E=8.1e-46
• PF02666: PS_Dcarbxylase
  • amino acids 71 to 291 (221 residues), 149.4 bits, E=5.6e-48

Best Hits

KEGG orthology group: K01613, phosphatidylserine decarboxylase [EC: 4.1.1.65] (inferred from 61% identity to bja:bll6631)

Predicted SEED Role

"Phosphatidylserine decarboxylase (EC 4.1.1.65)" in subsystem Glycerolipid and Glycerophospholipid Metabolism in Bacteria (EC 4.1.1.65)

MetaCyc Pathways

• superpathway of phospholipid biosynthesis III (E. coli) (10/12 steps found)
• phosphatidylserine and phosphatidylethanolamine biosynthesis I (2/2 steps found)
• cardiolipin and phosphatidylethanolamine biosynthesis (Xanthomonas) (3/4 steps found)
• superpathway of cardiolipin biosynthesis (bacteria) (9/13 steps found)
• superpathway of phospholipid biosynthesis II (plants) (10/28 steps found)

KEGG Metabolic Maps

• Glycerophospholipid metabolism

Isozymes

Compare fitness of predicted isozymes for: 4.1.1.65

Use Curated BLAST to search for 4.1.1.65

Protein Sequence (298 amino acids)

>GFF5595 Phosphatidylserine decarboxylase (EC 4.1.1.65) (Hydrogenophaga sp. GW460-11-11-14-LB1)
MNLSRQLQRLALNEDINFLLTNRVPRAALTRFMGWFSRIRHPWVRDASMAVWRTFTDIDL
SEAKKSTFDSLHDCFVRELKPGLRPVDPRPEVLASPSDAIVGACGRIGDDPGAQVFQAKG
FPYPLTDLLGPDPRARAMIDTLRGGSYVTLRLTSSMYHRFHAPAALALEHVTYHSGDTWN
VNPIALQRIERLFCKNERAALHARLADGTPLLLVPVAAILVASMRLRAVDVALNAQYRGP
HELPCNAGYGKGDEMGWFEHGSTILVFTPPGFVLCEGVDTGHRIRMGEALLRRVATTG