Protein Info for PS417_28430 in Pseudomonas simiae WCS417

Annotation: alpha-2-macroglobulin

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1200 1300 1400 1500 1600 1700 1800 1934 transmembrane" amino acids 12 to 33 (22 residues), see Phobius details amino acids 55 to 75 (21 residues), see Phobius details PF11974: bMG3" amino acids 569 to 670 (102 residues), 76 bits, see alignment 5.9e-25 PF01835: MG2" amino acids 681 to 779 (99 residues), 74.8 bits, see alignment 1.7e-24 PF17972: bMG5" amino acids 785 to 906 (122 residues), 68.7 bits, see alignment 2e-22 PF07703: A2M_BRD" amino acids 1045 to 1183 (139 residues), 63.5 bits, see alignment 8.3e-21 PF00207: A2M" amino acids 1253 to 1337 (85 residues), 45.1 bits, see alignment (E = 2.2e-15) PF17973: bMG10" amino acids 1769 to 1917 (149 residues), 72.9 bits, see alignment 8.8e-24

Best Hits

KEGG orthology group: K06894, (no description) (inferred from 97% identity to pfs:PFLU6111)

Predicted SEED Role

"Large extracellular alpha-helical protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1N7UNF4 at UniProt or InterPro

Protein Sequence (1934 amino acids)

>PS417_28430 alpha-2-macroglobulin (Pseudomonas simiae WCS417)
MFDSFKAISRGVVGALLTVVGAVFGQWHPPFWLRAIGRGLANLGNKARAYPRQTGAGLLG
LVLLAAAGFYGWHWYSNLPQPHTASYSLHKPNLTDYTQQTPLVDNLQVRFSESVAPLSAI
GKPVTEGITLKPAVAGTWRWADDRSLLFVPEKDWPIDAHYTLDMAKKDLLADGVLLDQYS
TQFSTQPFRATLAQNELYQDPSNPTLKQLVATFHFSHPVDEDNLRKRVTVTLGKGLAYRD
AQLPNRPEITFDEKKLNAYVRSAALATPLESTPVSAKLDEGIKARDGGNASNAPLVAEVT
VPGRYRLTFTGAEVSFVDNARGEPEPVLMFSSSNAVADDTIAGKVQAWLLPEKAQDDTRP
YSSNDIDDALLARSSKVNLTHVPSVEPLNTLHAFKFKAPAGRAVYVRVPANLEAIGGYLA
KNPTASLISMPAYPRTLQFLSEGALLSLNGEKRLGFMARGVPGAHVEIARLLPNQLQHLV
DQSSGSFARPNFGNEYFDRMVERQSLDIPLSSNDPAKTVYDNVDLSHYLTANGGRRGIFV
LKLSPQDDPAQRTFEYDRGSTSDLRFIVVTDLGIIAKRSSDGSHDVYVQSIGNGSPVADA
QVDIIGRNGLPVSSGHTDGEGHAHFAKLDELRREKTPLMYVVTRGNDQSFLPIARQSQQL
DLSRFDVGGLEEDGAIDRLSAYLFTDRGLYRPGETAHLGMIVRSGNWKGALQGLPVELQI
TDPRGLEVIRQPLKLSASGFETFDFPSSEVAPAGEYTATLQLIGQKQTRTDLGSVSFKVR
DFEPDRMKVSLSLHDTPVQGWIPPDQVVAKVTAMHLFGAPASGRRVTAKMSLSPTLAAFD
RYPDYRFRLNDSLEDATTEDLAETTVDDNGQAVLDLNLQRFANSTYRLQVMSQVFEAEGG
RNVAAQSALLVSSAPYLVGVKSQDSLSYVAKDAPRQVQWLAVAPDLSPLAVDGLTSEVVE
HRYVSVLVKQSNGTYKYESRIKNISQPASPLVMTKEGAKQTLNTSTPGDFTLQLKDANGN
LLNQIDYSVAGHGNTSRSLERNAELQLRLDKPSYATGDEIAISIRAPYTGAGLITIERDK
VYTQQWFKADSTNSVQHIRVPAGLEGNAYVNVQFVRDMGSAEVYMSPLSYGVVPFSINLD
ARRMALKVEGPAKIEPGQTLDIKVNADRPGRAVVYAVDEGILQVARYQTPDPLGFFFQKR
ALEVGTSQILDLILPEFSRLLSGAAPGGDTEGALANHLNPFKRKHQPPVAWWSGLVDLPA
GETVLHYQVPDSFNGKLHLFAVAVDTDSVGVSETNTEVRGPIVITPNVPAFVAPGDVFNV
SAGVFSNLDTTADVKFELQTSDGLKVQGDKGSTLSLQPRKEGTAEFKIKVGETLGSADLR
FVAVLPDGKRIQVAETTSIRPLSEHRVALSLGRFDSASKELKPTRELFSQLRDVQLGVAA
SPLVWANGLKHYLDDYGYACTEQLVSKAMPALIWGGNAPEAEQAFGSAVRMLRQRQNQAG
GFGLWAANPDVAPYASLYATDFLIEARERGLPVPEDLLVRSNAYLTDLANGPSEGLSELR
NRAYASYLLSRQGILVSGALSDIRERYENYFKDSWQNDLGAAYLAASYKLLKQDRQADTL
FRKIPWRSLVDKWDSDGLYYDPLVHDAEHLHLLARHFPELMDYVPTTLLDKLGKRLNEQR
YNSLSAALLLRALDNYGQRAQSDMTLKATAWLGDKQQQLLEMAGQPPRAAVPGATQKLVM
EKSDGPAAFYMLSEAGFDKGAKLKPINNGLEIIHEYLDLKGEPVSTVAVGDEFLVRLRLR
ATDRDQVQQVAVVDLLPGGVEPVYNLPPEPEAASSEDGEGEASEYVEEDSQEEESWQAPI
GETELSNWQPEYVDVRDDRVVLYGTALRDVGTFVYRVRATNAGTFNTPPAYAEGMYETTL
QGRGKVGQLEITQP