Protein Info for GFF5490 in Hydrogenophaga sp. GW460-11-11-14-LB1

Annotation: Multidrug resistance transporter, Bcr/CflA family

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 411 signal peptide" amino acids 1 to 21 (21 residues), see Phobius details transmembrane" amino acids 42 to 60 (19 residues), see Phobius details amino acids 72 to 91 (20 residues), see Phobius details amino acids 97 to 118 (22 residues), see Phobius details amino acids 130 to 151 (22 residues), see Phobius details amino acids 158 to 178 (21 residues), see Phobius details amino acids 210 to 238 (29 residues), see Phobius details amino acids 245 to 267 (23 residues), see Phobius details amino acids 276 to 297 (22 residues), see Phobius details amino acids 303 to 322 (20 residues), see Phobius details amino acids 334 to 357 (24 residues), see Phobius details amino acids 377 to 393 (17 residues), see Phobius details TIGR00710: drug resistance transporter, Bcr/CflA subfamily" amino acids 6 to 355 (350 residues), 231.6 bits, see alignment E=1.1e-72 PF07690: MFS_1" amino acids 11 to 351 (341 residues), 142.8 bits, see alignment E=1.4e-45 PF00083: Sugar_tr" amino acids 53 to 114 (62 residues), 35.1 bits, see alignment E=7.4e-13

Best Hits

KEGG orthology group: K07552, MFS transporter, DHA1 family, bicyclomycin/chloramphenicol resistance protein (inferred from 70% identity to pol:Bpro_3211)

Predicted SEED Role

"Multidrug resistance transporter, Bcr/CflA family" in subsystem Copper homeostasis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (411 amino acids)

>GFF5490 Multidrug resistance transporter, Bcr/CflA family (Hydrogenophaga sp. GW460-11-11-14-LB1)
MSPGLIVLVLSLLLGLQPIATDLYLPALPALTTGFGAPMPQAQLTLTALLLCFGLSQLVW
GPLSDRFGRRPVLLVGLSAFVAASIGSTFAPSMEQLIVWRAVQGAAMGAGVMCARAIVRD
LYAPSEGARVMSKGLTGLGVIACAASPVGGLLSDLFGWRVSLMALAVFGAVALLVVALRF
EETLAQKNPHALAPRTLLGNWVLIARHPTFWAFALLSTASYGGLFTFLAASSFVFIRVLG
LSTTAYGVVMFSMSLVYILGTFLCRALLPRLGLRRTVAIAAVMTLTAGTSMGGLALLGVQ
NTWAILVPFWLFMLAHGVHQPCGQSGAVGPFPQAAGAASALSGFLSMVTAFAMGGWLGRS
LAGIGEGRGSVLPLTNGLWFWSVLIALVAWTLVQRHGEAHSAPQRVTAPAR