Protein Info for GFF5465 in Hydrogenophaga sp. GW460-11-11-14-LB1

Annotation: Fumarylacetoacetate hydrolase family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 290 PF01557: FAA_hydrolase" amino acids 77 to 289 (213 residues), 254.8 bits, see alignment E=6.9e-80

Best Hits

KEGG orthology group: None (inferred from 73% identity to vap:Vapar_6065)

Predicted SEED Role

"Fumarylacetoacetate hydrolase family protein" in subsystem Gentisare degradation or Salicylate and gentisate catabolism

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (290 amino acids)

>GFF5465 Fumarylacetoacetate hydrolase family protein (Hydrogenophaga sp. GW460-11-11-14-LB1)
VRLATFVHQGQRQVGLVSADGQTVTPLALNPADAQRGVLPLIEAAAAGQPLPATTGAALK
LADVKLEAPLPLPRRNLWCVGRNYHEHAKELQGSVFKNNNANPAVWPIVFTKVPECVIAD
GADVLLPGDEISPQIDYEAELAVVIGTGGKNIAKADAMKHIYGYTIVNDVTARDVQMRHQ
QWDMGKSFDTFCPMGPWIVTADELDGQHTRVRCWVNGEPRQDGRTEDLIFDIPTLIETIS
RGITLYPGDVIATGTPAGVGLGMTPPTFLKSGDVVRIEIDGIGTLQNRFV