Protein Info for PS417_27665 in Pseudomonas simiae WCS417

Annotation: diguanylate cyclase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 554 TIGR00254: diguanylate cyclase (GGDEF) domain" amino acids 120 to 274 (155 residues), 79.8 bits, see alignment E=9.4e-27 PF00990: GGDEF" amino acids 125 to 274 (150 residues), 104.2 bits, see alignment E=6.5e-34 PF00563: EAL" amino acids 299 to 533 (235 residues), 258.9 bits, see alignment E=4e-81

Best Hits

KEGG orthology group: None (inferred from 99% identity to pfs:PFLU5960)

Predicted SEED Role

"GGDEF domain/EAL domain protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1N7U8N6 at UniProt or InterPro

Protein Sequence (554 amino acids)

>PS417_27665 diguanylate cyclase (Pseudomonas simiae WCS417)
MSTPVEPLRLLLLADEPAWAALLRECLAPMGDGAVLISAPNWESVSRLFDDDHSAVLLTT
PSLQPGPGRCSLPCVLLLEQEPLVSPLGVSDWLVRDVLDADTVRRCLRHVRERGVLENTL
QRLAEQDPLTGIANRQGFQTLLAARLVENEGRGLALGHLDLDNFRHANDALGHQAGDRLI
LQVVSRLKSQLEVGDQLARLGSDEFALLIDTRRAPQRAEWMAERITEVMAEPYWVDGESL
LIGCSLGVAHARARAGADPLMWHAHIAMQQAKSTQGCTFHIFNERINRNARSLADLESEL
RRALRRDELELHYQPRLDLDDGHIVGLEALVRWRHDERGLLPPSEFVPLAEQSGLIVPLG
YWVISRALRDMQDLRERGLPPLHMAVNLSFRQFQDSQLLSTLSRLIAERGVEAQWLEFEL
TETAVMRRSDLVKQTMDALGRLGVRFSLDDFGTGFSSFVHLNSLPIALLKIDKSFVGGME
EREENRKLVHAMINLAHNLNLEVVAEGVETPEQLALLRLFGCDQAQGYLISKPLPLAELV
EYLTFGKSQQALLG