Protein Info for PS417_27560 in Pseudomonas simiae WCS417

Annotation: adenylate cyclase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 946 PF12633: Adenyl_cycl_N" amino acids 20 to 216 (197 residues), 257.9 bits, see alignment E=7.9e-81 PF01295: Adenylate_cycl" amino acids 244 to 798 (555 residues), 400 bits, see alignment E=2.1e-123

Best Hits

KEGG orthology group: K05851, adenylate cyclase, class 1 [EC: 4.6.1.1] (inferred from 97% identity to pfs:PFLU5940)

Predicted SEED Role

"Adenylate cyclase (EC 4.6.1.1)" in subsystem cAMP signaling in bacteria (EC 4.6.1.1)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 4.6.1.1

Use Curated BLAST to search for 4.6.1.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1N7U8M0 at UniProt or InterPro

Protein Sequence (946 amino acids)

>PS417_27560 adenylate cyclase (Pseudomonas simiae WCS417)
MTRTHEIRPDLDEGIDRKVLAQLRARFMALNEGRMARAIEGLTPRQQSVLNLLPLFFHVN
HPLLPGYVSGSTPAGLSNYEPDAQALTEAQRLTRSFSYKPRHGNPPRPILGLFLMGSLGT
LAQADQSDMDVWVCHAADLSETELAELRKKCQLLEAWALTMGAEAHFFLIEPTRFVLGER
DTQLSSDDCGTTQHYLLLDEFYRTAIWLAGRTPIWWLVPVYEETRYAEFTHTLISKRFIR
ADETLDLGHLARIPPGEFIGAGLWQLFKGIESPYKSVLKLLLTEVYASEHPNVHCLSLRF
KRAVFANQMDLDELDPYIVVYRRIEEYLKARNEPERLELVRRALYLKVNRKLSASQRTTS
WQRLLLERLAHEWGWDQRQLALLDSRSQWKVRQVASERRALVSELNYSYRFLTQFARTEQ
TVSLINKRDLNVLGRRLYAAFERKAGKVEFINPGIAPDLAEDTLTLVQSPNRKEPGQHHW
GLYNGNLTALEWEHFAPIKRSRDLLEMLTWCHRNGVIDSSTRLALHPGTSDMTEFELFNL
LGSLQQTIDLPLTSVDEQRLLRSAVPEEVLLLINVGVDPLKHHRDLNILMTTERTDSLSY
AGVRDNLVLTLDQVTLNSWNEVMVSRYDGPHALLDCLRDYLNQLPPDHLPRLRVRCFCHN
RAQFIARRVEEIFDTAQNLLLSQGNHRYVLQVQQHYHVMELMPGQANHVSLATQDALVAY
LSEELASYSPLHLDAMALEDHDLAVLLPMGMADCVQVFYRVNEGFAELYVLDEFNALWQQ
RLPFHDEQSLLAPLQRFLQSIIYRRDALSPLDPQEPLGAVQVLYYQLLPSVSGRARGIEP
RPAPLNPTNKPFYDVQAIIGKAAQGQVGITLYCNQREFSELEFGDQLFAVVAQEIVGQRR
ETERYRCYITDLDLSGLLGDVQSPSNLYLRYKAELELSLNEALSQI