Protein Info for GFF5344 in Variovorax sp. SCN45

Annotation: ATP phosphoribosyltransferase (EC 2.4.2.17) => HisGs

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00070: ATP phosphoribosyltransferase
  • amino acids 2 to 187 (186 residues), 208.1 bits, E=5.1e-66
• PF01634: HisG
  • amino acids 51 to 206 (156 residues), 190.6 bits, E=9e-61

Best Hits

Swiss-Prot: 98% identical to HIS1_VARPS: ATP phosphoribosyltransferase (hisG) from Variovorax paradoxus (strain S110)

KEGG orthology group: K00765, ATP phosphoribosyltransferase [EC: 2.4.2.17] (inferred from 98% identity to vpe:Varpa_1250)

Predicted SEED Role

"ATP phosphoribosyltransferase (EC 2.4.2.17)" in subsystem Histidine Biosynthesis (EC 2.4.2.17)

MetaCyc Pathways

• superpathway of histidine, purine, and pyrimidine biosynthesis (43/46 steps found)
• L-histidine biosynthesis (10/10 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from histidine and purine
• Biosynthesis of plant hormones
• Histidine metabolism

Isozymes

Compare fitness of predicted isozymes for: 2.4.2.17

Use Curated BLAST to search for 2.4.2.17

Protein Sequence (213 amino acids)

>GFF5344 ATP phosphoribosyltransferase (EC 2.4.2.17) => HisGs (Variovorax sp. SCN45)
MITLALSKGRIFEETMPLLAAAGIEVTEDPEKSRKLILETTRPDVRVVLVRASDVPTYVQ
YGGADLGVTGLDVLLENGNQGMYQPLDLRIAACRLSVAVRADYDYASAVKQGSRLRVATK
YVGLARDFFASKGVHVDLIKLYGSMELAPLTGLADAIVDLVSTGNTLKANHLVEVERIMD
ISARLVVNQAALKLKREPIRHIIDAFASAIPSS