Protein Info for GFF528 in Xanthobacter sp. DMC5

Annotation: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00243: 1-deoxy-D-xylulose 5-phosphate reductoisomerase
  • amino acids 1 to 377 (377 residues), 415.3 bits, E=1.1e-128
• PF02670: DXP_reductoisom
  • amino acids 4 to 129 (126 residues), 110.7 bits, E=1.3e-35
• PF08436: DXP_redisom_C
  • amino acids 143 to 226 (84 residues), 129.4 bits, E=7.1e-42
• PF13288: DXPR_C
  • amino acids 258 to 375 (118 residues), 123.9 bits, E=6.3e-40

Best Hits

Swiss-Prot: 52% identical to DXR_BRASO: 1-deoxy-D-xylulose 5-phosphate reductoisomerase (dxr) from Bradyrhizobium sp. (strain ORS 278)

KEGG orthology group: K00099, 1-deoxy-D-xylulose-5-phosphate reductoisomerase [EC: 1.1.1.267] (inferred from 82% identity to xau:Xaut_4433)

Predicted SEED Role

"1-deoxy-D-xylulose 5-phosphate reductoisomerase (EC 1.1.1.267)" in subsystem Isoprenoid Biosynthesis or polyprenyl synthesis (EC 1.1.1.267)

MetaCyc Pathways

• methylerythritol phosphate pathway II (9/9 steps found)
• superpathway of geranylgeranyl diphosphate biosynthesis II (via MEP) (11/12 steps found)
• taxadiene biosynthesis (engineered) (11/13 steps found)
• methylerythritol phosphate pathway I (8/9 steps found)
• isoprene biosynthesis I (8/10 steps found)
• superpathway of ergosterol biosynthesis II (10/26 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from terpenoid and polyketide
• Biosynthesis of plant hormones
• Biosynthesis of terpenoids and steroids
• Terpenoid biosynthesis

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.267

Protein Sequence (389 amino acids)

>GFF528 1-deoxy-D-xylulose 5-phosphate reductoisomerase (Xanthobacter sp. DMC5)
MKRLSVLGATGSIGHSVRKVLADAPDLYRVEAVVGGRDAAALAETARALGASFAVVADPA
AGAALREALSGTGIESGAGPEAVLEAARRDTDVVVSAIVGCAGLAPTVAAFAPGRRIALA
NKECLVAAGAFFMAEAARLETELLPVDSEHNAIFQALAAGPQRAVEKITLTASGGPFRLK
SREEIARALPQDALKHPNWNMGAKVTIDSATLMNKGLELIEAQHLFSVTADQLDAVVHAE
SVVHGLVSFIDGSVTAGLALPDMCVPIAHCLAYPERVATSCRKLDLVALGRLSFEAPDVA
RFPALALAREVLKQGGVAATILNAANEIAVAAYLDGRIGFYGITDIVAATLDRINGGPAP
SSVADALEADQLGRRTASGLLPKFAAKAS