Protein Info for PS417_26845 in Pseudomonas simiae WCS417

Annotation: coniferyl aldehyde dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00171: Aldedh
  • amino acids 19 to 444 (426 residues), 294.8 bits, E=4.9e-92

Best Hits

Swiss-Prot: 77% identical to CALB_PSEAE: Probable coniferyl aldehyde dehydrogenase (calB) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)

KEGG orthology group: K00154, coniferyl-aldehyde dehydrogenase [EC: 1.2.1.68] (inferred from 98% identity to pfs:PFLU5788)

Predicted SEED Role

"Aldehyde dehydrogenase (EC 1.2.1.3); Probable coniferyl aldehyde dehydrogenase (EC 1.2.1.68)" (EC 1.2.1.3, EC 1.2.1.68)

MetaCyc Pathways

• superpathway of NAD/NADP - NADH/NADPH interconversion (yeast) (7/8 steps found)
• ethanol degradation II (3/3 steps found)
• ethanol degradation IV (3/3 steps found)
• mitochondrial NADPH production (yeast) (4/5 steps found)
• octane oxidation (4/5 steps found)
• phytol degradation (3/4 steps found)
• ethanol degradation III (2/3 steps found)
• hypotaurine degradation (2/3 steps found)
• fatty acid α-oxidation I (plants) (2/4 steps found)
• putrescine degradation III (2/4 steps found)
• histamine degradation (1/3 steps found)
• 3-methyl-branched fatty acid α-oxidation (3/6 steps found)
• L-tryptophan degradation X (mammalian, via tryptamine) (1/4 steps found)
• ferulate and sinapate biosynthesis (1/4 steps found)
• serotonin degradation (3/7 steps found)
• dopamine degradation (1/5 steps found)
• ceramide degradation by α-oxidation (2/7 steps found)
• sphingosine and sphingosine-1-phosphate metabolism (4/10 steps found)
• alkane oxidation (1/6 steps found)
• aromatic biogenic amine degradation (bacteria) (2/8 steps found)
• limonene degradation IV (anaerobic) (1/7 steps found)
• noradrenaline and adrenaline degradation (4/13 steps found)
• ceramide and sphingolipid recycling and degradation (yeast) (4/16 steps found)

KEGG Metabolic Maps

• 1,2-Dichloroethane degradation
• 3-Chloroacrylic acid degradation
• Arginine and proline metabolism
• Ascorbate and aldarate metabolism
• Butanoate metabolism
• Fatty acid metabolism
• Glycerolipid metabolism
• Glycolysis / Gluconeogenesis
• Histidine metabolism
• Limonene and pinene degradation
• Lysine degradation
• Phenylpropanoid biosynthesis
• Propanoate metabolism
• Pyruvate metabolism
• Tryptophan metabolism
• Urea cycle and metabolism of amino groups
• Valine, leucine and isoleucine degradation
• beta-Alanine metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.2.1.3

Use Curated BLAST to search for 1.2.1.3 or 1.2.1.68

Sequence Analysis Tools

See A0A1N7UDS8 at UniProt or InterPro

Protein Sequence (475 amino acids)

>PS417_26845 coniferyl aldehyde dehydrogenase (Pseudomonas simiae WCS417)
MSANVAYLQDTQVLDQLQALFDTQRRAYAANPMPPAAQRQQWLKALRDLLSDERQALINA
ISQDFSHRSADETLFAELMPSLHGIHYASKHLKGWMKPSRRAVGIAFQPASAKVIYQPLG
VVGVIVPWNYPLYLAIGPLVGALAAGNRVMLKLSESTPATGELLKALLAKIFPEDLVCVV
LGEAEVGMAFSKLPFDHLLFTGATSIGKHVMRAAAEHLTPVTLELGGKSPAIVSADVPLK
DAAERIAFGKALNAGQTCVAPDYVLVPEDRVEGFVEAYTQAVRGFYPTLADNPDYTAIIN
ERQLARLNAYVKDATDKGATLIPLYDQGQARRMAHSLLLNVSDDMTVMQDEIFGPVLPIV
PYRGIDQAFAYINQRPRPLALYYFGYNKGEQNRVLHETHSGGVCLNDTLLHVAQDDMPFG
GIGPSGMGHYHGHEGFLTFSKAKGVLVKQRLNAAKLIYPPYGKSIQTLIQKLFIR