Protein Info for GFF5225 in Hydrogenophaga sp. GW460-11-11-14-LB1

Annotation: 2-hydroxychromene-2-carboxylate isomerase/DsbA-like thioredoxin domain

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 221 PF01323: DSBA" amino acids 11 to 215 (205 residues), 105 bits, see alignment E=4.5e-34

Best Hits

KEGG orthology group: None (inferred from 74% identity to rfr:Rfer_0115)

Predicted SEED Role

"2-hydroxychromene-2-carboxylate isomerase/DsbA-like thioredoxin domain"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (221 amino acids)

>GFF5225 2-hydroxychromene-2-carboxylate isomerase/DsbA-like thioredoxin domain (Hydrogenophaga sp. GW460-11-11-14-LB1)
MAPMNTTPLKIDFVSDVSCPWCAVGLGALEEALQKLQGDVAADLHFQPFELNPQMGPEGQ
DIGEHLAEKYGSTAEQQAQIRNTIRARGAEVGFAFNPEGRGRIWNTFDAHRLLHWAGEEG
APGQQHALKKALMAACHTRSEAMGHHDVLLGCVREAGLDETRAKAILASDEFANDVRERE
AFYTSHGIRSVPAVIINDKHLISGGQPAAVFEQALRQIAAE