Protein Info for PS417_26615 in Pseudomonas simiae WCS417

Annotation: triphosphoribosyl-dephospho-CoA synthase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 277 TIGR03132: triphosphoribosyl-dephospho-CoA synthase MdcB" amino acids 12 to 273 (262 residues), 332.5 bits, see alignment E=1e-103 PF01874: CitG" amino acids 16 to 271 (256 residues), 260 bits, see alignment E=1.7e-81

Best Hits

Swiss-Prot: 80% identical to MDCB_PSEPF: Probable 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase (mdcB) from Pseudomonas fluorescens (strain Pf0-1)

KEGG orthology group: K13930, triphosphoribosyl-dephospho-CoA synthase [EC: 2.7.8.25] (inferred from 92% identity to pfs:PFLU5742)

Predicted SEED Role

"Triphosphoribosyl-dephospho-CoA synthetase (EC 2.7.8.25)" in subsystem Malonate decarboxylase (EC 2.7.8.25)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.8.25

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1N7U2Q0 at UniProt or InterPro

Protein Sequence (277 amino acids)

>PS417_26615 triphosphoribosyl-dephospho-CoA synthase (Pseudomonas simiae WCS417)
MRALKLHELTLAERLADMAVDALIDEADLSPKPALVDRRGNGAHHDLHLGLMHASALSLW
PMFKEMAEAAIEWGEVGVPLREALGRIGREGEQAMLVTTNGVNTHRGAIWALGLLTAAAA
LEPRAVTLNAARLALLNDRYAPQPMSHGAQVAQRYGARGAREEAQLGFPSVVQRGLPQLY
KSRQQNAGEQNARLDALLAIMTELADTCVLYRAGPEGISTMQRGARAVLDAGGSATLAGR
RQLHELDQHLLALNASPGGAADLLAACLFIDRLDGAL