Protein Info for GFF5190 in Hydrogenophaga sp. GW460-11-11-14-LB1

Annotation: Aldehyde dehydrogenase B (EC 1.2.1.22)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00171: Aldedh
  • amino acids 27 to 488 (462 residues), 559 bits, E=3.6e-172
• TIGR01780: succinate-semialdehyde dehydrogenase
  • amino acids 36 to 487 (452 residues), 702.7 bits, E=1e-215

Best Hits

Swiss-Prot: 61% identical to SLAD_PSEPU: 3-sulfolactaldehyde dehydrogenase (PpSQ1_00395) from Pseudomonas putida

KEGG orthology group: K00135, succinate-semialdehyde dehydrogenase (NADP+) [EC: 1.2.1.16] (inferred from 88% identity to dia:Dtpsy_1778)

MetaCyc: 60% identical to succinate-semialdehyde dehydrogenase (NADP+) GabD (Escherichia coli K-12 substr. MG1655)
SUCCSEMIALDDEHYDROG-RXN [EC: 1.2.1.79]; Glutarate-semialdehyde dehydrogenase. [EC: 1.2.1.79, 1.2.1.20]

Predicted SEED Role

"Aldehyde dehydrogenase B (EC 1.2.1.22)" in subsystem Glycerolipid and Glycerophospholipid Metabolism in Bacteria or Methylglyoxal Metabolism (EC 1.2.1.22)

MetaCyc Pathways

• TCA cycle IV (2-oxoglutarate decarboxylase) (8/9 steps found)
• 4-aminobutanoate degradation II (2/2 steps found)
• 4-aminobutanoate degradation III (2/2 steps found)
• L-lysine degradation IV (4/5 steps found)
• 4-hydroxyphenylacetate degradation (6/8 steps found)
• methylglyoxal degradation V (2/3 steps found)
• superpathway of 4-aminobutanoate degradation (2/3 steps found)
• L-lysine degradation X (4/6 steps found)
• L-lactaldehyde degradation (aerobic) (1/2 steps found)
• methylglyoxal degradation IV (1/3 steps found)
• superpathway of L-arginine and L-ornithine degradation (8/13 steps found)
• lactate biosynthesis (archaea) (2/5 steps found)
• L-rhamnose degradation II (4/8 steps found)
• superpathway of methylglyoxal degradation (4/8 steps found)
• superpathway of L-arginine, putrescine, and 4-aminobutanoate degradation (6/11 steps found)
• L-lysine degradation I (3/7 steps found)
• L-lysine degradation III (1/6 steps found)
• nicotine degradation II (pyrrolidine pathway) (3/11 steps found)
• superpathway of fucose and rhamnose degradation (3/12 steps found)
• nicotine degradation I (pyridine pathway) (6/17 steps found)
• superpathway of L-lysine degradation (12/43 steps found)

KEGG Metabolic Maps

• Butanoate metabolism
• Glutamate metabolism
• Lysine degradation
• Pyruvate metabolism
• Tyrosine metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.2.1.16, 1.2.1.22

Use Curated BLAST to search for 1.2.1.16 or 1.2.1.20 or 1.2.1.22 or 1.2.1.79

Protein Sequence (496 amino acids)

>GFF5190 Aldehyde dehydrogenase B (EC 1.2.1.22) (Hydrogenophaga sp. GW460-11-11-14-LB1)
MDMKTSPLALLKDPTLLKTDALINGQWVAGGSRFDVHDPATGHKLADVANLGPADAEAAI
AAANAAWPAWKAKTAKERSQILRKWYDLLMANQDDLGTLMTAEQGKSLAEAKGEVAYGAS
FVEWFAEEAKRVNGETLPTFDNNRRLMVLKQPIGVCAAITPWNFPLAMITRKVAPALAAG
CPVIIKPAELTPLTALAAAELAIRAGIPAGVFNILTADSEQSIAVGKVLCASDVVRHISF
TGSTEVGRILMAQCAPTVKKMSLELGGNAPFIVFDDADIDSAVEGAFASKYRNAGQTCVC
TNRFYVQAGVYDAFVAKFAAKVKTSKVGNGFGEGVSQGPLIEEAALVKVQRHVDDAVAKG
ARVVAGGQRLTSLGSGQFFEPTVVADATADMLCAKEETFGPFAPVFKFHTEQEAIDAANA
TEFGLASYFYSRDVGRIFRVSEALEYGMVGINVGILATEHVPFGGVKQSGLGREGSHHGM
DDYVEIKYLCVGDILK