Protein Info for GFF5175 in Variovorax sp. SCN45

Annotation: Transcriptional repressor of PutA and PutP / Proline dehydrogenase (EC 1.5.5.2) / Delta-1-pyrroline-5-carboxylate dehydrogenase (EC 1.2.1.88)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1244 signal peptide" amino acids 1 to 20 (20 residues), see Phobius details PF18327: PRODH" amino acids 25 to 72 (48 residues), 48.7 bits, see alignment (E = 1.5e-16) PF14850: Pro_dh-DNA_bdg" amino acids 84 to 195 (112 residues), 154 bits, see alignment E=4.1e-49 PF01619: Pro_dh" amino acids 205 to 501 (297 residues), 358.2 bits, see alignment E=7.3e-111 TIGR01238: delta-1-pyrroline-5-carboxylate dehydrogenase" amino acids 543 to 1042 (500 residues), 770.6 bits, see alignment E=3e-236 PF00171: Aldedh" amino acids 591 to 1039 (449 residues), 368.8 bits, see alignment E=7.2e-114

Best Hits

Swiss-Prot: 67% identical to PUTA_ECOLI: Bifunctional protein PutA (putA) from Escherichia coli (strain K12)

KEGG orthology group: K13821, proline dehydrogenase / delta 1-pyrroline-5-carboxylate dehydrogenase [EC: 1.5.1.12 1.5.99.8] (inferred from 69% identity to ajs:Ajs_2420)

MetaCyc: 67% identical to fused DNA-binding transcriptional repressor / proline dehydrogenase / 1-pyrroline-5-carboxylate dehydrogenase PutA (Escherichia coli K-12 substr. MG1655)
RXN0-7008 [EC: 1.5.5.2]; RXN-14116 [EC: 1.5.5.2, 1.2.1.88]

Predicted SEED Role

"Transcriptional repressor of PutA and PutP / Proline dehydrogenase (EC 1.5.99.8) (Proline oxidase) / Delta-1-pyrroline-5-carboxylate dehydrogenase (EC 1.5.1.12)" in subsystem Arginine and Ornithine Degradation or Proline, 4-hydroxyproline uptake and utilization or Respiratory dehydrogenases 1 (EC 1.5.1.12, EC 1.5.99.8)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.2.1.88 or 1.5.1.12 or 1.5.5.2 or 1.5.99.8

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1244 amino acids)

>GFF5175 Transcriptional repressor of PutA and PutP / Proline dehydrogenase (EC 1.5.5.2) / Delta-1-pyrroline-5-carboxylate dehydrogenase (EC 1.2.1.88) (Variovorax sp. SCN45)
MSPTSAAPLPSPLASFADGLAAHPSALREQITAATRRAEPEALPPLLAQARLPRAQADEA
HALAHRIAQQLRSRKNASGRAGLVQGLLQEYALSSQEGVALMCLAEALLRIPDAETRNAL
IRDKIAHGQWQTHAGRSPSVFVNAATWGLLLTGKLVATHSETGLSAVLTRLIGKGGEPLI
RKGVDMAMRMMGEQFVTGETIQQALGNARELEAQGFRYSYDMLGEAALTMEDARRYRLAY
EEAIHAIGKASNARGVYEGPGISIKLSALHPRYSRAQHARVMAELYPVLRELALLAQHYD
IGLNIDAEEADRLELSLDLLEHLCFEPALAGWNGIGFVIQAYQKRCPFVIDHVIDLARRS
RHRLMVRLVKGAYWDSEIKRAQIDGQDGYPVYTRKAYTDVSYLACARKLLDAPEAVYPQF
ATHNAHTLAAIYTMADPSRYQPGQYEFQCLHGMGEPLYEQVVGPLGRPCRIYAPVGTHET
LLAYLVRRLLENGANTSFVNRIADPTISLEALVEDPVATVEHMGAQEGAVGLPHPAIALP
AALYGTQRLNSRGLDLANDDSLRLLGQALQATAHEDWHAGPMLAAATGAQGEPADVLNPA
DHRDMVGQVREATPADVESAVSQAEGIAAAWAATPPAERATMLERAAELLEEQMPRLLGL
LAREAGKTYANAIAEVREAVDFLRFYAAQARNDFSNDTHRALGPMVCISPWNFPLAIFTG
QVAAALAAGNPVLAKPAEQTPLVAAEAVRMLWQAGVPRAAVQLLPGQGETVGASLVADAR
VQGVMFTGSTEVARILQKTLSQRLGAHGAPVPLIAETGGQNAMIVDSSALVEQVVTDVMA
SAFDSAGQRCSALRVLCVQEEAADRLVEMLKGAMAEACIGNPARLSVDVGPVIDAEARDG
IERHIGAMRSRGHKIYRQGREHGQDARHGTFVMPTLIELDSISELQREVFGPVLHLVRYR
RRDLGALVGQINGTGYGLTLGVHTRIDETIAQIVQHAKAGNVYVNRNIVGAVVGVQPFGG
EGLSGTGPKAGGPLYMLRMLSRRPEDAMARAMDGASASSASNAGLSALARWAQKNGCDAL
AAQCARFASLSRAGDSRTLAGPTGERNVYTLQPREAVLCLAGDTADRLTQLAAVLSVGST
AIWPADAAAQGLRASLPAEVQQSVAIASDWNSPTVAFDAALHHGDAGDLADVMHRIAARS
GPIVGVRAFAPGDAQIPLESLVVERALSVNTAAAGGNASLMTIG