Protein Info for GFF5151 in Variovorax sp. SCN45

Annotation: Histidinol-phosphatase [alternative form] (EC 3.1.3.15)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00459: Inositol_P
  • amino acids 10 to 255 (246 residues), 173.4 bits, E=3.5e-55
• TIGR02067: histidinol-phosphatase
  • amino acids 11 to 256 (246 residues), 287.9 bits, E=3.3e-90

Best Hits

KEGG orthology group: None (inferred from 93% identity to vpe:Varpa_1044)

Predicted SEED Role

"Histidinol-phosphatase [alternative form] (EC 3.1.3.15)" in subsystem Histidine Biosynthesis (EC 3.1.3.15)

MetaCyc Pathways

• superpathway of histidine, purine, and pyrimidine biosynthesis (43/46 steps found)
• L-histidine biosynthesis (10/10 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from histidine and purine
• Histidine metabolism

Isozymes

Compare fitness of predicted isozymes for: 3.1.3.15

Use Curated BLAST to search for 3.1.3.15

Protein Sequence (258 amino acids)

>GFF5151 Histidinol-phosphatase [alternative form] (EC 3.1.3.15) (Variovorax sp. SCN45)
MSSSSPDLSPIAEALADAAAAQSMHYFRTPLDIITKADESPVTLADRAAETAMRQILGAR
VPADGIYGEEHGPERLDAGRVWVLDPIDGTRSFITGSPLWGTLIGVLEGSRVVLGMVDMP
VLKERWIGQAGKGATRDGQPVRVSNCTEVAKARIVTTSPDIFAPADWAAFDKLSRQCAMR
RFGGDCYGYAQLAGGTIDLVVETGLQPYDYLGPAGLIEAAGGVITDWQGQPLGLKSDGRV
IAAATPELHRQAMALLSA