Protein Info for GFF515 in Sphingobium sp. HT1-2

Annotation: GTP-binding protein TypA/BipA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 605 PF00009: GTP_EFTU" amino acids 2 to 194 (193 residues), 188.9 bits, see alignment E=2.2e-59 TIGR00231: small GTP-binding protein domain" amino acids 2 to 141 (140 residues), 78.3 bits, see alignment E=5.6e-26 TIGR01394: GTP-binding protein TypA/BipA" amino acids 3 to 598 (596 residues), 925.3 bits, see alignment E=1.3e-282 PF01926: MMR_HSR1" amino acids 6 to 127 (122 residues), 25.9 bits, see alignment E=2.8e-09 PF22042: EF-G_D2" amino acids 204 to 286 (83 residues), 32.4 bits, see alignment E=2.4e-11 PF03144: GTP_EFTU_D2" amino acids 217 to 287 (71 residues), 34.8 bits, see alignment E=5.5e-12 PF00679: EFG_C" amino acids 397 to 479 (83 residues), 72.3 bits, see alignment E=8.2e-24 PF21018: BipA_C" amino acids 484 to 592 (109 residues), 152.8 bits, see alignment E=7.9e-49

Best Hits

Swiss-Prot: 55% identical to TYPA_ECOL6: GTP-binding protein TypA/BipA (typA) from Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)

KEGG orthology group: K06207, GTP-binding protein (inferred from 94% identity to sch:Sphch_0036)

Predicted SEED Role

"GTP-binding protein TypA/BipA" in subsystem Universal GTPases

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (605 amino acids)

>GFF515 GTP-binding protein TypA/BipA (Sphingobium sp. HT1-2)
MSLRNIAIIAHVDHGKTTLVDQLFRQSGTFRDNQRVEERAMDSNDLEKERGITILAKPTS
VEWNGTRINIVDTPGHADFGGEVERILSMVDGVILLVDSSEGAMPQTKFVTGKALALGLK
PIVVVNKVDRPDERIQEVLDEVFDLFVTLDATDEQLDFPVLYASGRNGYASEDSQRREGT
LEPLFQKIVDHVPPPSLDQDAPFSFLVTLLDRDNFLGRILTGRVQSGTVKVNQPIHALDA
EGNVIETGRASKIMSFQGLDRVPVEEAKAGDIISLAGLTVATVANTISDPQVSTPIKAQP
IDPPTLSMRFAVNDSPMAGREGSKVTSRMIRDRLAREAESNVAIKVTESDDKDSFEVAGR
GELQLGVLIETMRREGFELGISRPRVLFGEDENGGKTEPYETVVIDVDDEFSGTVVDKMN
IRKAEMTDMRPSGGGKTRITFSAPSRGLIGYHGEFLSDTRGTGIMNRLFEKYGPHKGKIE
GRKNGVLISNGAGEANAYALGPLEDRGILFVGVGEALYEGMIIGENAKPEDLEVNPMKSK
ALTNFRASGKDDAVRLTPPKKMTLEQAIAYIDDDEMVEVTPKTIRLRKRYLDPNERKRMS
RSKAA