Protein Info for GFF5086 in Variovorax sp. SCN45

Annotation: Glycine betaine transporter OpuD

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 504 signal peptide" amino acids 1 to 25 (25 residues), see Phobius details transmembrane" amino acids 40 to 59 (20 residues), see Phobius details amino acids 79 to 100 (22 residues), see Phobius details amino acids 134 to 152 (19 residues), see Phobius details amino acids 178 to 199 (22 residues), see Phobius details amino acids 219 to 238 (20 residues), see Phobius details amino acids 250 to 270 (21 residues), see Phobius details amino acids 305 to 323 (19 residues), see Phobius details amino acids 334 to 358 (25 residues), see Phobius details amino acids 388 to 410 (23 residues), see Phobius details amino acids 433 to 452 (20 residues), see Phobius details amino acids 458 to 481 (24 residues), see Phobius details PF02028: BCCT" amino acids 4 to 483 (480 residues), 597 bits, see alignment E=1.2e-183 TIGR00842: transporter, betaine/carnitine/choline transporter (BCCT) family" amino acids 40 to 482 (443 residues), 485.3 bits, see alignment E=8.3e-150

Best Hits

KEGG orthology group: None (inferred from 76% identity to aav:Aave_2025)

Predicted SEED Role

"Glycine betaine transporter OpuD" in subsystem Choline and Betaine Uptake and Betaine Biosynthesis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (504 amino acids)

>GFF5086 Glycine betaine transporter OpuD (Variovorax sp. SCN45)
MQLVVSAGLIAAVVLWGLLSPASLDSVFSTALSGITRNFGWFYLWVVLGLVVLAFFLAFS
RFGDLKLGEEDDEPEFSLGAWFAMLFAAGMGIGLVFWGVAEPISHYANPPPGVVAGTPDA
AGVAMRYAFFHWGLHPWAIYGIVGLSIAFFTFRRKTLALVSSATEALPWRFVRRLSPAFN
VLAVVATAFGVAASLGMGATQINSGLHAAFGTAIGRGTQAAIIVVTTVLFVTSAVSGVER
GVKWLSMGNLVLAALLALVVLVLGPTVAIVETFTNTLGAYIAEFVRMSLRMNPFRNSSWV
GDWTLFYWAWWLAWSPFVGLFIARVSRGRTIRQFILGTVIAPTLVGFAWFSVFGGAALNF
QIFQGVPLVEAVKADVSTTMFVMFKAMPMGALLSMVATLLVFVFFVTSGDSATLVLGTMS
TGGNPNPPARVKITWGVLVAAIALSLLFAGGLKAIQTATIVFALPFAFVILLMALSVTLA
IRDDWNAEQKRERELRRKMRQLVS