Protein Info for GFF5038 in Variovorax sp. SCN45

Annotation: Tetracycline resistance, MFS efflux pump => Tet(C)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 410 transmembrane" amino acids 20 to 41 (22 residues), see Phobius details amino acids 55 to 76 (22 residues), see Phobius details amino acids 87 to 106 (20 residues), see Phobius details amino acids 112 to 133 (22 residues), see Phobius details amino acids 145 to 166 (22 residues), see Phobius details amino acids 173 to 193 (21 residues), see Phobius details amino acids 226 to 250 (25 residues), see Phobius details amino acids 259 to 280 (22 residues), see Phobius details amino acids 292 to 311 (20 residues), see Phobius details amino acids 317 to 338 (22 residues), see Phobius details amino acids 352 to 376 (25 residues), see Phobius details amino acids 382 to 400 (19 residues), see Phobius details PF07690: MFS_1" amino acids 24 to 253 (230 residues), 119.8 bits, see alignment E=2e-38 amino acids 242 to 402 (161 residues), 39 bits, see alignment E=7.5e-14 PF00083: Sugar_tr" amino acids 55 to 196 (142 residues), 51.9 bits, see alignment E=9.2e-18

Best Hits

KEGG orthology group: K08151, MFS transporter, DHA1 family, tetracycline resistance protein (inferred from 53% identity to bcm:Bcenmc03_0731)

Predicted SEED Role

No annotation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (410 amino acids)

>GFF5038 Tetracycline resistance, MFS efflux pump => Tet(C) (Variovorax sp. SCN45)
MINSTTYPPPSDAKGRHAHAVILAIVTLDAIGISLVMPIVPSLLREVGHTGDLGWRFGAF
LSLYALMQFLCAPVLGALSDRFGRRPVLLISVAGSAIDALFMAFAPSLWMLFLGRAIAGM
TGASTAVASAAIADLTPENQRARWFGRMGACFGLGFIAGPAIGGVLGDYGVRLPFVAAAV
LNGLTFLVGLLVLRESRPPALASQPFDRGVLHPLAPLRWATSFPALLPLLGVFLLLVLVG
EVAGTTWVIYGQDRYAWNGTMVGLSLAVFGLLHALVQGFVAGPLVERWGERAAIAVGIIA
DGTGYALIAFATQGWMAIAMLPLLCMGGVCAPALQATLSARVGQAQQGRLQGVLASITSL
AAVFGPLLISPLYFAFRTRFPGIVWLAGASLYLLCLPVLLRRTGRTGAQG