Protein Info for GFF503 in Sphingobium sp. HT1-2

Annotation: SAM-dependent methyltransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 318 PF10017: Methyltransf_33" amino acids 17 to 316 (300 residues), 355.8 bits, see alignment E=9e-111 TIGR03438: dimethylhistidine N-methyltransferase" amino acids 17 to 314 (298 residues), 370.3 bits, see alignment E=3.6e-115

Best Hits

KEGG orthology group: None (inferred from 84% identity to sjp:SJA_C1-35150)

Predicted SEED Role

"FIG00636833: hypothetical protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (318 amino acids)

>GFF503 SAM-dependent methyltransferase (Sphingobium sp. HT1-2)
MLLTHDMPAARTIDPAFRRDILAGLARSPKATPPIWFYDRRGSELFEDITDLPEYYPTRT
ETALLAGHGDDFAAAIGPGRAVVEFGAGSARKTPHLLRAINPAAYVPIDISGDFLRASSA
ELASAFPGLPVLPLVGDFTGTLALPDAIDGLPRLGFFPGSTIGNSEPDTAVDLLRAMRRL
LGDDAMLLIGMDRIKDRDRLIAAYDDEAGVTAAFNRNLLVRINRELEGDLPVDAFAHRAI
WNDEKARIEMHLEATEPLHFHVAGQCFHMKAGETIHTESSHKYGARDERLLLRAGGWEPT
TEWMDPDGLFALVLAKAG