Protein Info for GFF5001 in Variovorax sp. SCN45

Annotation: Oxidoreductase, molybdopterin-binding

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF04879: Molybdop_Fe4S4
  • amino acids 19 to 68 (50 residues), 26.7 bits, 6.6e-10
• PF00384: Molybdopterin
  • amino acids 75 to 479 (405 residues), 124 bits, E=1.1e-39
• PF01568: Molydop_binding
  • amino acids 570 to 679 (110 residues), 83.2 bits, E=2e-27

Best Hits

KEGG orthology group: None (inferred from 92% identity to vpe:Varpa_0350)

Predicted SEED Role

"Anaerobic dehydrogenases, typically selenocysteine-containing" in subsystem Anaerobic respiratory reductases

MetaCyc Pathways

• formate oxidation to CO₂ (1/1 steps found)
• purine nucleobases degradation II (anaerobic) (16/24 steps found)
• oxalate degradation VI (1/4 steps found)
• oxalate degradation III (1/5 steps found)
• superpathway of C1 compounds oxidation to CO₂ (4/12 steps found)
• purine nucleobases degradation I (anaerobic) (6/15 steps found)

Protein Sequence (686 amino acids)

>GFF5001 Oxidoreductase, molybdopterin-binding (Variovorax sp. SCN45)
MPHAPDSLLEEASPPVTSTVLGACPHDCPDTCALVTTVKDGVAVKLQGNAAHSHTGGVLC
TKVSRYIERNDHAERLVQPLKRVGPKGSGQFEPVSWDAALDDIAAHLRVLQGKPEVIVPY
SYAGTMGLVQGESMDRRFFHKLGATLLDRTICSMAGGEAMVYTLGAKVGMRIEFFAEAKL
ILIWGSNSIASNLHFWRHAQAAKRAGARLVCIDPRKTETADKCDEHIALLPGTDAALALA
LMHELIVHDWLDHDYIANHTLGWEQLRERALQWPPSRAAQVCGVPEEQIVALAKAYGTTR
PAAIRLNYGMQRVRGGGNAARAIACLPALVGAWRDRAGGLLLSSSGHYPVDRAALQRPDL
LAGRKPRTINMSTIGDALLDTANPVKAIVVYNSNPVAVAPESAKVAAGFAREDLFTVVLE
QFRTDTADYADYLLPATTQLEHWDIHCSYGHTDVLLNRPAVAPRGEARSNAWVFRELARR
MGFTEPCFSDSDETLCRTAFAENAIDFPQLLEQGFTSVKLPEAPFAEGKFPTPSGRCEFF
SARLEAMGMNGLPDHVPNWEPAGSSTEFPLAMISPPARNFLNSTFVNVTSLRAIEVEPLL
EIHEADAAARGIEDGALVRVFNKRGEHRCRAEVSRRARQGVVHGMGIWWRKLGMDGTNVN
ELTSQRLTDIGRGPTFYDCLVEVEKA