Protein Info for GFF497 in Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868

Annotation: 2-dehydro-3-deoxygluconate kinase (EC 2.7.1.45)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00294: PfkB
  • amino acids 3 to 304 (302 residues), 240.7 bits, E=1.2e-75

Best Hits

Swiss-Prot: 92% identical to KDGK_ECOLI: 2-dehydro-3-deoxygluconokinase (kdgK) from Escherichia coli (strain K12)

KEGG orthology group: K00874, 2-dehydro-3-deoxygluconokinase [EC: 2.7.1.45] (inferred from 99% identity to spt:SPA3468)

MetaCyc: 92% identical to 2-dehydro-3-deoxygluconokinase (Escherichia coli K-12 substr. MG1655)
2-dehydro-3-deoxygluconokinase. [EC: 2.7.1.178, 2.7.1.45]

Predicted SEED Role

"2-dehydro-3-deoxygluconate kinase (EC 2.7.1.45)" in subsystem D-Galacturonate and D-Glucuronate Utilization or D-gluconate and ketogluconates metabolism or Entner-Doudoroff Pathway (EC 2.7.1.45)

MetaCyc Pathways

• D-fructuronate degradation (4/4 steps found)
• superpathway of β-D-glucuronosides degradation (6/7 steps found)
• D-galactonate degradation (3/3 steps found)
• superpathway of hexuronide and hexuronate degradation (8/10 steps found)
• 4-deoxy-L-threo-hex-4-enopyranuronate degradation (4/5 steps found)
• D-galacturonate degradation I (4/5 steps found)
• Entner-Doudoroff pathway III (semi-phosphorylative) (6/9 steps found)
• 3,6-anhydro-α-L-galactopyranose degradation (4/7 steps found)
• L-glucose degradation (3/7 steps found)
• alginate degradation (1/7 steps found)
• superpathway of microbial D-galacturonate and D-glucuronate degradation (17/31 steps found)

KEGG Metabolic Maps

• Pentose and glucuronate interconversions
• Pentose phosphate pathway

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.1.178 or 2.7.1.45

Protein Sequence (309 amino acids)

>GFF497 2-dehydro-3-deoxygluconate kinase (EC 2.7.1.45) (Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868)
MSKKIAVIGECMIELSQKGADVQRGFGGDTLNTSVYIARQVDSAALAVHYVTALGTDSFS
QQMLEAWQHENVDTSLTQRMENRLPGLYYIETDDTGERTFYYWRNEAAAKFWLESEQSAA
ICETLATFDYLYLSGISLAILSPTSRDKLLSLLRECRANGGKVIFDNNYRPRLWTSREET
QQVYQKMLECTDIAFLTLDDEDALWGQQPVEEVIARTHAAGVQEVVVKRGADSCLVSIQG
EALIDVPAVKLPKEKVIDTTAAGDSFSAGYLAVRLTGGSATDAAKRGHLTASTVIQYRGA
IIPHDAMPQ