Protein Info for GFF4962 in Variovorax sp. SCN45

Annotation: Multidrug resistance transporter, Bcr/CflA family

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 402 transmembrane" amino acids 12 to 32 (21 residues), see Phobius details amino acids 46 to 66 (21 residues), see Phobius details amino acids 78 to 96 (19 residues), see Phobius details amino acids 102 to 123 (22 residues), see Phobius details amino acids 135 to 157 (23 residues), see Phobius details amino acids 164 to 185 (22 residues), see Phobius details amino acids 215 to 235 (21 residues), see Phobius details amino acids 252 to 273 (22 residues), see Phobius details amino acids 284 to 303 (20 residues), see Phobius details amino acids 309 to 332 (24 residues), see Phobius details amino acids 343 to 365 (23 residues), see Phobius details amino acids 371 to 389 (19 residues), see Phobius details TIGR00710: drug resistance transporter, Bcr/CflA subfamily" amino acids 10 to 386 (377 residues), 301.7 bits, see alignment E=5.5e-94 PF07690: MFS_1" amino acids 17 to 357 (341 residues), 171.6 bits, see alignment E=3.4e-54 PF00083: Sugar_tr" amino acids 49 to 188 (140 residues), 46.6 bits, see alignment E=3.5e-16 PF13347: MFS_2" amino acids 134 to 328 (195 residues), 30.7 bits, see alignment E=1.9e-11

Best Hits

KEGG orthology group: K07552, MFS transporter, DHA1 family, bicyclomycin/chloramphenicol resistance protein (inferred from 54% identity to mpt:Mpe_A3595)

Predicted SEED Role

"Multidrug resistance transporter, Bcr/CflA family" in subsystem Copper homeostasis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (402 amino acids)

>GFF4962 Multidrug resistance transporter, Bcr/CflA family (Variovorax sp. SCN45)
MSSSNAQVSRYAIVLGLLTTIGPFAIDMYLPALPAIGHALGADPHAMQASLMAFFIAVGA
GQLVAGPLSDMFGRRRPMVAGLVLFMLASIGCALAPDVGVLIALRFLQGLGACACMVTPR
AVVRDLYTGPEAARMMSLLLMVYSVSPILAPLVGSFVAESVGWRAVFGVVAALGLAGLAM
LMAFLPETRPAAARLSSNFRSAMAGYGLLLRDRRFMALAFMASFTVSAFFVYVANSPFVM
SAHYGVSPRQYALLFALNAVSLLALSQANGWLVTRFGIRRVLRTAVMVQAGSIGLLLVLT
LAGIDRLAVMVVLLMIGYGVNGLIVPATFVLAMEGHASLAGTASALIGTMNFAGGALMVA
LVAPFANGKPLPMVAGIAACAAVVFVLAMRSPGVRHPAAVAA