Protein Info for GFF4947 in Variovorax sp. SCN45

Annotation: Erythritol kinase EryA (EC 2.7.1.27)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00370: FGGY_N
  • amino acids 6 to 250 (245 residues), 108.3 bits, E=5e-35
• PF02782: FGGY_C
  • amino acids 263 to 440 (178 residues), 60.1 bits, E=2.6e-20

Best Hits

KEGG orthology group: K00880, L-xylulokinase [EC: 2.7.1.53] (inferred from 84% identity to vpe:Varpa_0393)

Predicted SEED Role

"Erythritol kinase EryA (EC 2.7.1.27)" in subsystem Erythritol utilization (EC 2.7.1.27)

MetaCyc Pathways

• L-lyxose degradation (1/4 steps found)
• superpathway of pentose and pentitol degradation (16/42 steps found)

KEGG Metabolic Maps

• Ascorbate and aldarate metabolism
• Pentose and glucuronate interconversions

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.1.27 or 2.7.1.53

Protein Sequence (495 amino acids)

>GFF4947 Erythritol kinase EryA (EC 2.7.1.27) (Variovorax sp. SCN45)
MKPKILIGIDMGSSSLKALALEAGSGRCVALSRMPLPHDRLPGGGCEVGAAAIRSALTHV
LRDVAHQLGDRAAEVRAIGCTGHGAGLYALDARNELVGGRAVASTDQRADARARSLSLSH
GDALFADVGCRPWPGQPTVIAAELLGTDAVQRGAVRRLLFAKDYLGFLLTGEIATDASDA
STAGLVSIATGTWSQAAFDASGIADLGPRAFGPLVPSGEAVGRLLPSEAALCGLPAGIPV
AMGAIDLLASMTAICAEGRERAVSVFGTWCVNAVIGPVIEPKPGVAAVVNFGRGDRRLYM
ENSPSSMANIAWLAGVLGLADSRAVVDLAMSVPLGAGGLRFLPFVNGGGGVTAGFVGLKS
HHTRGDMARAVVDAVAALHARHTARLAACGLPVSASTVLGGGASDTRLVRLLAGFLGHPV
ERCADDETGARGAAIYAAMSQGIDRAEQGSALLAPCDTVEPDAAQARAHAGFMAGFNELI
DTMSPVFSHLAGGEK