Protein Info for GFF4934 in Hydrogenophaga sp. GW460-11-11-14-LB1

Annotation: Transcription-repair coupling factor

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1160 PF17757: UvrB_inter" amino acids 132 to 220 (89 residues), 82.4 bits, see alignment 7.3e-27 TIGR00580: transcription-repair coupling factor" amino acids 150 to 1087 (938 residues), 1025 bits, see alignment E=0 PF21132: MFD_D3" amino acids 377 to 450 (74 residues), 54.4 bits, see alignment 3.4e-18 PF02559: CarD_TRCF_RID" amino acids 479 to 541 (63 residues), 59.5 bits, see alignment 9.8e-20 PF00270: DEAD" amino acids 612 to 771 (160 residues), 85.2 bits, see alignment E=1.6e-27 PF04851: ResIII" amino acids 613 to 767 (155 residues), 37.1 bits, see alignment E=1.1e-12 PF00271: Helicase_C" amino acids 811 to 915 (105 residues), 68.3 bits, see alignment E=2.4e-22 PF03461: TRCF" amino acids 1015 to 1107 (93 residues), 80.9 bits, see alignment E=2.5e-26

Best Hits

KEGG orthology group: K03723, transcription-repair coupling factor (superfamily II helicase) [EC: 3.6.4.-] (inferred from 88% identity to aaa:Acav_1627)

Predicted SEED Role

"Transcription-repair coupling factor" in subsystem DNA-replication or Transcription factors bacterial

Isozymes

Compare fitness of predicted isozymes for: 3.6.4.-

Use Curated BLAST to search for 3.6.4.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1160 amino acids)

>GFF4934 Transcription-repair coupling factor (Hydrogenophaga sp. GW460-11-11-14-LB1)
MDLPKLTPGKRHTVPHPGGSADALMLAQLGAREKAEGRLTAIVTADANDAQRLIDEMAFF
APGLRCALFPDWETLPYDTFSPHQDLISERLATLWRISQRDKDTGADVVLIPATTALYRL
APPSFLAGYTFHFKVKQKLDEARLKGQLTLAGYQHVTQVVSPGEYAVRGGLIDLFPMGSL
VPYRVDLFDDEIDSIRTFDPDSQRSLYPVNEVRLLPGREFPMDDAARAKFRSRWRELLEG
DPTKSRIYKDIGNGVATAGIEYYLPLFFDDTATVFDYLGTDATVVLHGDLEPAFQRFWQD
TKDRHRLLRGDAERPVLPPEALFLATEQFYTRANEHAQYVVRPAQQDIEHGAHVQKLGDL
SVVRGAEDPLARLQAHIRNTAHRVLLLAESDGRRESLLDFLRASGVHPPAFDSLAEFQAS
DEKTGIATAALAVGFSWLDDGIDFVTETELFAAGPTTRRRRKQEQVSDVDALIKDLSELN
VGDPVVHNAHGIGRYRGLVNMDMGEKNPDGSPALQEFLHLEYADKAVLYVPVSQLQLIGR
YTGVSADEAPLHKLGSGQWDKAKRKAAEQVRDAAAELLNIYARRAARQGHAFRYSAQDYE
VFANDFGFEETADQRGAIHAVIQDMISPRPMDRLVCGDVGFGKTEVALRAAFVAVTGGRQ
VAFLAPTTLLAEQHFQTLSDRFSKWPVKVAEMSRFRSAKEITAAAKGLADGSVDIVVGTH
KLLSESVKFKDLGLLIIDEEHRFGVRHKEAMKALRAEVDVLTLTATPIPRTLGMALEGLR
DLSVIATAPQRRLAIKTFVRNEGNGVIREAVLRELKRGGQVYFLHNEVETIENRRQKLEE
ILPEARIAIAHGQMPERELERVMRDFVAQRFNVLLCSTIIETGIDVPTANTIVMSRADKF
GLAQLHQLRGRVGRSHHQAYAYLMVPDIEGLTKHAAQRLDAIQQMEELGSGFYLAMHDLE
IRGAGEVLGEHQSGNMLEVGFQLYNEMLSEAVSSLKAGREPDLLSPLSVTTDINLHAPAL
LPNDYCGDVHLRLSFYKKLATAKSTDQVDALLEEIVDRFGKLPPQAQTLIDVHRLRCIST
PYGVVKVDAAPGVTNITFRANPPFEPMRIIELIQKNRHIKLAGNDKLRIERPLPEVKDRV
QLVRDVLRSLGQPHKNPETA