Protein Info for PS417_25200 in Pseudomonas simiae WCS417

Annotation: geranyl transferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00348: polyprenyl_synt
  • amino acids 29 to 260 (232 residues), 201.8 bits, E=5.6e-64

Best Hits

Swiss-Prot: 57% identical to ISPA_ECOLI: Farnesyl diphosphate synthase (ispA) from Escherichia coli (strain K12)

KEGG orthology group: K13789, geranylgeranyl diphosphate synthase, type II [EC: 2.5.1.1 2.5.1.10 2.5.1.29] (inferred from 96% identity to pfs:PFLU5461)

MetaCyc: 57% identical to geranyl diphosphate/farnesyl diphosphate synthase (Escherichia coli K-12 substr. MG1655)
Geranyltranstransferase. [EC: 2.5.1.10]; Dimethylallyltranstransferase. [EC: 2.5.1.10, 2.5.1.1]

Predicted SEED Role

No annotation

MetaCyc Pathways

• superpathway of geranylgeranyl diphosphate biosynthesis II (via MEP) (11/12 steps found)
• superpathway of chorismate metabolism (44/59 steps found)
• taxadiene biosynthesis (engineered) (11/13 steps found)
• polyisoprenoid biosynthesis (E. coli) (5/5 steps found)
• superpathway of ubiquinol-8 biosynthesis (early decarboxylation) (10/12 steps found)
• trans, trans-farnesyl diphosphate biosynthesis (2/2 steps found)
• geranyl diphosphate biosynthesis (1/1 steps found)
• geranylgeranyl diphosphate biosynthesis (1/1 steps found)
• (3R)-linalool biosynthesis (1/2 steps found)
• (3S)-linalool biosynthesis (1/2 steps found)
• linalool biosynthesis I (1/2 steps found)
• all-trans-farnesol biosynthesis (2/4 steps found)
• methyl phomopsenoate biosynthesis (2/4 steps found)
• ophiobolin F biosynthesis (1/3 steps found)
• plaunotol biosynthesis (1/3 steps found)
• superpathway of linalool biosynthesis (1/3 steps found)
• ipsdienol biosynthesis (1/4 steps found)
• bisabolene biosynthesis (engineered) (2/6 steps found)
• mono-trans, poly-cis decaprenyl phosphate biosynthesis (1/5 steps found)
• stellatic acid biosynthesis (3/8 steps found)
• superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate) (4/10 steps found)
• paspaline biosynthesis (1/6 steps found)
• brassicicene C biosynthesis (1/7 steps found)
• fusicoccin A biosynthesis (1/8 steps found)
• viridicatumtoxin biosynthesis (1/9 steps found)
• superpathway of phylloquinol biosynthesis (4/15 steps found)
• superpathway of ergosterol biosynthesis II (10/26 steps found)
• superpathway of mycolyl-arabinogalactan-peptidoglycan complex biosynthesis (12/33 steps found)
• superpathway of ergosterol biosynthesis I (3/26 steps found)
• Methanobacterium thermoautotrophicum biosynthetic metabolism (20/56 steps found)
• superpathway of cholesterol biosynthesis (3/38 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from terpenoid and polyketide
• Biosynthesis of plant hormones
• Biosynthesis of terpenoids and steroids
• Terpenoid biosynthesis

Isozymes

Compare fitness of predicted isozymes for: 2.5.1.1, 2.5.1.10, 2.5.1.29

Use Curated BLAST to search for 2.5.1.1 or 2.5.1.10 or 2.5.1.29

Sequence Analysis Tools

See A0A1N7UFT4 at UniProt or InterPro

Protein Sequence (295 amino acids)

>PS417_25200 geranyl transferase (Pseudomonas simiae WCS417)
MIDAYQASSQARVNAALEPLFVAPSPELKRLYEAMRYSVMNGGKRVRPLLAYAACEALGA
AAEQANGAACAVELIHAYSLVHDDLPAMDDDDLRRGQPTTHKAFDEACAILAGDGLQSLA
FSALLDPALSSVNAEIRLRMVTALAVAAGPAGMVGGQAIDLGSVGRKLDQQALEYMHRHK
TGALIEAAVHLGALASGRAQAAQLAALKTYALAIGLAFQVQDDILDVESDTATLGKRQGA
DIARDKPTYPALLGLEAAKAYALELRDQALDALRPFDAAAEPLRDLARYIVERRH