Protein Info for GFF4909 in Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868

Annotation: Hydroxylamine reductase (EC 1.7.-.-)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 TIGR01703: hydroxylamine reductase" amino acids 1 to 548 (548 residues), 767.4 bits, see alignment E=3.4e-235 PF03063: Prismane" amino acids 1 to 545 (545 residues), 521.6 bits, see alignment E=1.1e-160

Best Hits

Swiss-Prot: 100% identical to HCP_SALNS: Hydroxylamine reductase (hcp) from Salmonella newport (strain SL254)

KEGG orthology group: K00378, hydroxylamine reductase [EC: 1.7.-.-] (inferred from 97% identity to cro:ROD_08831)

MetaCyc: 96% identical to protein S-nitrosylase (Escherichia coli K-12 substr. MG1655)
Hydroxylamine reductase. [EC: 1.7.99.1]

Predicted SEED Role

"Hydroxylamine reductase (EC 1.7.-.-)" in subsystem Nitrosative stress (EC 1.7.-.-)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.7.-.-

Use Curated BLAST to search for 1.7.-.- or 1.7.99.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (550 amino acids)

>GFF4909 Hydroxylamine reductase (EC 1.7.-.-) (Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868)
MFCVQCEQTIRTPAGNGCSYAQGMCGKTAETSDLQDLLIAALQGLSAWAVKAREYGIINH
DVDNFAPRAFFSTLTNVNFDSPRIVGYAREAIALREALKAQCLSVDANAHCDNPMADLQL
VSDDLGDLQRQAAEFTPNKDKAAIGENILGLRLLCLYGLKGAAAYMEHAHVLGQYDNDIY
AQYHKIMAWLGTWPADMNALLECAMEIGQMNFKVMSILDAGETTKYGHPTPTQVNVKATE
GKCILISGHDLKDLYNLLEQTEGTGVNVYTHGEMLPAHGYPELRKFKHLVGNYGSGWQNQ
QVEFARFPGPIVMTSNCIIDPTVGSYDDRIWTRSIVGWPGVSHLEGDDFGPVIAQAQQMA
GFPYSEIPHIITVGFGRQTLLGAADTLIDLVSREKLRHIFLVGGCDGARGERNYFTDFAT
SVPDDCLILTLACGKYRFNKLEFGDIEGLPRLVDAGQCNDAYSAIILAVTLAEKLGCGVN
DLPLSLVLSWFEQKAIVILLTLLSLGVKNIVTGPTAPGFFTPDLLAILNEKFGLRSVTTV
EEDMKQLLSA