Protein Info for GFF4798 in Hydrogenophaga sp. GW460-11-11-14-LB1

Annotation: COG1496: Uncharacterized conserved protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF02578: Cu-oxidase_4
  • amino acids 6 to 238 (233 residues), 249.1 bits, E=2.1e-78
• TIGR00726: YfiH family protein
  • amino acids 11 to 239 (229 residues), 180.3 bits, E=1.8e-57

Best Hits

Swiss-Prot: 51% identical to POLOX_ECOLI: Polyphenol oxidase (yfiH) from Escherichia coli (strain K12)

KEGG orthology group: K05810, conserved hypothetical protein (inferred from 61% identity to aav:Aave_2475)

MetaCyc: 51% identical to purine nucleoside phosphorylase YfiH (Escherichia coli K-12 substr. MG1655)
Adenosine deaminase. [EC: 3.5.4.4]; S-methyl-5'-thioadenosine phosphorylase. [EC: 3.5.4.4, 2.4.2.28]; Purine-nucleoside phosphorylase. [EC: 3.5.4.4, 2.4.2.28, 2.4.2.1]; 2.4.2.1 [EC: 3.5.4.4, 2.4.2.28, 2.4.2.1]; Laccase. [EC: 3.5.4.4, 2.4.2.28, 2.4.2.1, 1.10.3.2]

Predicted SEED Role

"COG1496: Uncharacterized conserved protein"

MetaCyc Pathways

• superpathway of purine nucleotide salvage (13/14 steps found)
• adenosine nucleotides degradation II (5/5 steps found)
• purine nucleotides degradation II (aerobic) (9/11 steps found)
• adenine and adenosine salvage I (2/2 steps found)
• S-methyl-5'-thioadenosine degradation II (1/1 steps found)
• adenine and adenosine salvage III (3/4 steps found)
• guanosine nucleotides degradation III (3/4 steps found)
• inosine 5'-phosphate degradation (3/4 steps found)
• ureide biosynthesis (5/7 steps found)
• adenine and adenosine salvage V (2/3 steps found)
• guanine and guanosine salvage I (1/2 steps found)
• xanthine and xanthosine salvage (1/2 steps found)
• purine deoxyribonucleosides degradation II (1/3 steps found)
• superpathway of guanine and guanosine salvage (1/3 steps found)
• purine ribonucleosides degradation (3/6 steps found)
• purine deoxyribonucleosides degradation I (1/4 steps found)
• superpathway of purine deoxyribonucleosides degradation (1/7 steps found)
• sesamin biosynthesis (1/8 steps found)
• L-methionine salvage cycle III (3/11 steps found)
• nucleoside and nucleotide degradation (archaea) (2/10 steps found)
• justicidin B biosynthesis (1/10 steps found)
• matairesinol biosynthesis (1/10 steps found)
• salinosporamide A biosynthesis (3/15 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from histidine and purine
• Methionine metabolism
• Nicotinate and nicotinamide metabolism
• Purine metabolism
• Pyrimidine metabolism
• Urea cycle and metabolism of amino groups

Isozymes

Compare fitness of predicted isozymes for: 3.5.4.4

Use Curated BLAST to search for 1.10.3.2 or 2.4.2.1 or 2.4.2.28 or 3.5.4.4

Protein Sequence (240 amino acids)

>GFF4798 COG1496: Uncharacterized conserved protein (Hydrogenophaga sp. GW460-11-11-14-LB1)
VRALFTTRDGGVSIAPFDSFNLGDHVRDEPHAVAENRARLAALTAPARPVFLQQVHGTGV
VHLDHATPHGTQADGCVAHGPGQVATIMVADCLPVLFAHASGRAVAAAHAGWRGLAGGVL
ETTLRALRETAGEGEVIAWLGPCIGPSAFEVGAEVREAFLAVDADAASHFRFHGQDGKYW
ANLPALARRRLQGAGVVQLHGNDGSDAWCTVTQASRFFSHRRDAVRLGSTGRMAACIWID