Protein Info for GFF4752 in Hydrogenophaga sp. GW460-11-11-14-LB1

Annotation: Malonyl CoA-acyl carrier protein transacylase (EC 2.3.1.39)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 200 400 600 800 1000 1200 1400 1600 1800 2000 2132 PF00109: ketoacyl-synt" amino acids 32 to 281 (250 residues), 325 bits, see alignment E=3e-100 PF00108: Thiolase_N" amino acids 181 to 233 (53 residues), 28.1 bits, see alignment (E = 1.1e-09) PF02801: Ketoacyl-synt_C" amino acids 289 to 406 (118 residues), 132.6 bits, see alignment 5.9e-42 PF16197: KAsynt_C_assoc" amino acids 412 to 510 (99 residues), 60.8 bits, see alignment 1.3e-19 PF22621: CurL-like_PKS_C" amino acids 473 to 535 (63 residues), 53.2 bits, see alignment (E = 1.9e-17) PF22336: RhiE-like_linker" amino acids 477 to 539 (63 residues), 28.9 bits, see alignment (E = 6.9e-10) PF00698: Acyl_transf_1" amino acids 562 to 865 (304 residues), 269.9 bits, see alignment E=3e-83 PF21089: PKS_DH_N" amino acids 924 to 1025 (102 residues), 66.3 bits, see alignment 1.6e-21 PF14765: PS-DH" amino acids 1055 to 1194 (140 residues), 80.3 bits, see alignment 1e-25 PF08240: ADH_N" amino acids 1433 to 1511 (79 residues), 39.4 bits, see alignment (E = 4.9e-13) PF00107: ADH_zinc_N" amino acids 1553 to 1640 (88 residues), 60.1 bits, see alignment (E = 1.8e-19) PF13602: ADH_zinc_N_2" amino acids 1586 to 1722 (137 residues), 65.6 bits, see alignment 7.4e-21 PF08659: KR" amino acids 1734 to 1912 (179 residues), 203.1 bits, see alignment E=2.8e-63 PF00106: adh_short" amino acids 1737 to 1831 (95 residues), 39.6 bits, see alignment (E = 3.3e-13) PF00550: PP-binding" amino acids 2022 to 2080 (59 residues), 42.6 bits, see alignment (E = 4.8e-14)

Best Hits

Predicted SEED Role

"Malonyl CoA-acyl carrier protein transacylase (EC 2.3.1.39)" in subsystem Fatty Acid Biosynthesis FASII or mycolic acid synthesis (EC 2.3.1.39)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.3.1.39

Use Curated BLAST to search for 2.3.1.39

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (2132 amino acids)

>GFF4752 Malonyl CoA-acyl carrier protein transacylase (EC 2.3.1.39) (Hydrogenophaga sp. GW460-11-11-14-LB1)
MASDALKGLSALKLALMARQVRESAEPVLRADPIAVVGMGCRAPGGVDSPADLWALLSEG
REVIREVPADRWDGDAWYSPDAAAPAKSLTKWGGFLDRIDGFDAAYFGVLPREAERMDPQ
QRLLLEVAIEALDDAGLSEAHLKGSRTGVYIASYHNDYAQLQHNDLAAIDARTLTGTLHS
VVANRLSYLLDLRGPSLSIDTACSSSLVAIHLACQSLRSGESDLAVAGGVSLMISPELMV
SLSKVGFMAPDGRCKTFDESADGFGRGEGCGVVVLKRLADAVADGDRVLGVLRGSAVNSD
GHSTLLAAPNGLAQQAMVREALDNAQLEPQRIGFVEAHGTGTALGDPIEVEALAATVGQP
APGAGTCYIGAAKANIGHLEAGAGVVGLIKTVLALQHEAIPPQPNFTRLSHHISLAGTRL
AVPTALTPWPRGAQARCAAVSSFGVGGTNAHVIVEEAPALPAEPSTLAADAWHLLPLSAR
SPEALRAVAQRWAGFLTQSGTALPDAVFTAAERRTHHDQRLAVVGQSAQELAARLGRFAL
GEDAPGVASGQRSSIALPRVAFVFCGQGPQWYAMGRELLGSEPVFRDVVAECDALLRPLS
GWSLLDALNADEAHSRLNETEVAQPALFALQVALVALWKSWGIAPDGLVGHSIGEMAALH
AAGVLTLPDAIRVVWHRGRTMQQATGLGRMASVGLGAEAADEFVKPWNGQLSVAALNGPR
SVVLSGDAKALDEALDQLSARGVAHRMLPVQYAFHSAQMAPFQQRLTDELAGLRCVAPNL
PVYSTVTGALLESTPLDVAYFGRNVRQTVRFAPAIQAMADDGFDVFLEIGPHPVLGASIA
ECLAGADHEPRLLASLRRGKPERETLLQAGAGLYAAGFMPAWDALQPEGGQVVPLPAYPW
QRKRHWIRPRPVANASVPSAPGAHPLLGRRVPMASQRVRVYEGDATAAHGWLADHRIFDR
LLMPAAAMMDLLGAAARDALRADAVRLTGFTLSRPLVIAEAGEPATRWQVSAALDEGGAV
DLELHQALEGDAWQPVASARAVAANGADAADAVATGQPVDASSVYQRFAELGVAFGPGFR
VLQDVTAGPGVAAGWVELTDVGPGHALHPVLIDGALQLCSVAAGHAAGGLPPSLYLPLGV
DDLMLRPTASRRLRASARVTDTGSSLTASVTLCEPDGTVVARLDGMRFAPADASAFAAAE
AGDGLLYDLSWQPQPLAAATADLQGRWLLLADRGGVADQLADRLAQAGAHCVRVRPGDAV
DATGPWRGVVHLASLDAAPLDGADEHDDGLTVGSALALVQGLVATPAPLWLVSRGAQAVS
GHEPADTLRPRAAGLWGLASVVAVEHPELQVHAIDLDPTDAANAALNLLTELRQPPTSPQ
RIALRGAQRWSARLVRHRQAEARRDEPRRWVVAQAGTLDGAQLQAAPPAALQAGEVRLSV
RAAGINFRDVLLTLGMYSAPGVPLGAECAGVVTELGAGVQGLALGDTVFGFAPGSLGTDV
TVPAAFVAKLPAGVSVEDAAALPVAFLTAHHGLHRLANLQAGQRVLIHAAAGGVGLAAVQ
LALRAGAQVFATAGSPDKRERLRQMGVALAMDSRSLAFADELRAATNGQGVHVVLNSLAG
DFIPATLGALGQGGTFLELGKRDILTVASAAALRPDVRYHAYDLGSEAQADHGLLRPMFN
DLLAAFADGSLSPLPVRAYPLESAPEAFRFMAQARHVGKLVLRVAQPAAIAADATYWITG
GLGGLGLETARWLVASGARHLALSGRSAPGEQARAVIAELRAQGATVNTFEADAADRERM
AQVLDELSRTLPPLRGVVHAAGALDDAVLLRQTWPRCQAVLRAKAHGAWVLHELTRHLPL
DLFVLYSAAGLWLGAAGQGAYPAANAELDALAHARRRQGLAALSVAWGAWAEVGMAARSA
SGGHDVWAARGLGQLTPATGFAALAQLMRDGVAHALVLPIDWSRFLAQLPAGADAGFFQA
LAVPTATPAAAPAGPAVRERLQALPGGQRRAALIAYLSERTLQVLGLESTQPLDPRLALK
EIGLDSLMAVELRNALAKAFAHPLPATLLFDYPTLDALAASLLRTLGLEAEAAPATPVAV
APPAHDELADLSDEEAEALLLKELESGSSEHT