Protein Info for GFF4728 in Variovorax sp. SCN45

Annotation: Two-component system sensor histidine kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 361 TIGR00229: PAS domain S-box protein" amino acids 17 to 134 (118 residues), 60.4 bits, see alignment E=9.8e-21 PF00989: PAS" amino acids 17 to 119 (103 residues), 28.4 bits, see alignment E=2.8e-10 PF08448: PAS_4" amino acids 22 to 127 (106 residues), 32.3 bits, see alignment E=2e-11 PF07730: HisKA_3" amino acids 156 to 220 (65 residues), 31 bits, see alignment E=5.9e-11 PF02518: HATPase_c" amino acids 261 to 352 (92 residues), 45.5 bits, see alignment E=1.9e-15

Best Hits

KEGG orthology group: None (inferred from 45% identity to eba:ebA5715)

Predicted SEED Role

No annotation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (361 amino acids)

>GFF4728 Two-component system sensor histidine kinase (Variovorax sp. SCN45)
MRQTPNDAPFDMQSVPFRGIVEQSVAGIYILQDEHFQYTNATFAGMAGYSNDEALGKPLR
ECVPGYYVGEVMERYKRRISGEVKSMHFVTHGLHRDGNVVHIDVHGQAMQFRGRPAVVGV
GVNVTEQIQRDAELLESRHEYRELASRLNTMREQQRAEYAREVHDVLGGLLTSMKLDVGR
IARRSRSTAIRGIAADLNALLVEAIDNVRELSESMHPQALDHLGLGAAIAGHLKRFRERS
ELRVSMQPQEFDIDLPRWRSIAVFRIFQEALTNVARHARASAVTVRFRRTEKTFWLEIED
DGIGFDAGDAGMQALRQSLGLISMRERAYELGGSLAIDSAPRFGTRVTLQAPIVASPLVR
A